SAVE THE DATE! 21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.

glvR

transcriptional activator of the malA-glvR-malP operon

locus: BSU_08190

pI: 5.45

mw: 29.15 kDa

protein length: 254 aa

gene length: 765 bp

function: regulation of maltose utilization

product: transcriptional activator

essential: no

synonyms: yfiA,malR

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.22|Utilization of maltose]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

Gene

Coordinates: 891,436 892,200

The protein

[SW|Domains]

• HTH rpiR-type domain (aa 1-77) (according to UniProt)
• [SW|SIS domain] (aa 106-248) (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|C650160C9E5B5F8587CA9E80A57BCCE97D701037|malA]-[gene|AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR]-[gene|E6C7733A12AF9A5322EED444E4A4FF1605A8B20F|malP]
  description: [Pubmed|11489864]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|11489864], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|AD72489DA260F07B97A213F1F0FBA7CED9471817|GlvR]: activation, [Pubmed|11489864], in [regulon|AD72489DA260F07B97A213F1F0FBA7CED9471817|GlvR regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|11489864], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

  regulation

  • induction by maltose ([protein|search|GlvR]) [Pubmed|11489864]

Biological materials

Mutant

• MGNA-C290 (yfiA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2288 NBRP B. subtilis, Japan]
• BKE08190 ([gene|AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE08190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCAGATCCCCCCATTT, downstream forward: _UP4_AATGACAATGAGTAGCAGGGG
• BKK08190 ([gene|AD72489DA260F07B97A213F1F0FBA7CED9471817|glvR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK08190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCAGATCCCCCCATTT, downstream forward: _UP4_AATGACAATGAGTAGCAGGGG

References

• 11489864