priA

primosomal replication factor Y, part of the [SW|replisome]

locus: BSU_15710

pI: 8.28

mw: 91.16 kDa

protein length: 805 aa

gene length: 2418 bp

function: [category|SW 3.1.1|DNA replication]initiation

product: primosomal replication factor Y

essential: yes

ec: 3.6.4.-

synonyms: yloJ

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 1,644,068 → 1,646,485

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Protein family

• [SW|helicase family] (according to UniProt)

[SW|Domains]

• [SW|Helicase ATP-binding domain] (aa 282-448) (according to UniProt)
• [SW|Helicase C-terminal domain] (aa 545-699) (according to UniProt)

Structure

• [PDB|4NL4] (from ''Klebsiella pneumoniae'', 38% identity) [Pubmed|24379377]

Expression and Regulation

Operons

• genes: [gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]-[gene|2B67C63442F28F6BCBA3BA6DE4B563C73E8DF16C|yloI]-[gene|AF5ADDA2A98EC18BB72A81AA0336E639C0D1F430|priA]-[gene|3D41FB608DB70B9482312A1BBCCDBDA7FB713AFA|defA]-[gene|06971E9AAB033E2878914A76645F99E97CE8A90A|fmt]-[gene|1370D8783450D538C71E3DE8EA5B37DFEE073FF0|yloM]-[gene|5DEBD84E5937DB8B7F29C729FAA0076DF86A5451|yloN]

  description

  • [pubmed|22383849]

additional information

• the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]

References

Reviews

• 28320884

Original Publications

• 17853894,20122408,11585815,10572298,24379377,26883633,27484483