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veg
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veg

negative effector of [protein|5A6FBAE6553343092862CB79E150F934978C32A9|SinR] activity
locus
BSU_00440
pI
4.81
mw
9.41 kDa
protein length
86 aa Sequence Blast
gene length
261 bp Sequence Blast
function
control of [SW|biofilm formation]
product
negative effector of [protein|5A6FBAE6553343092862CB79E150F934978C32A9|SinR] activity
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.4|Regulation]

    • Gene

    Coordinates
    52,763 → 53,023

    The protein

    Catalyzed reaction/ biological activity

  • overexpression of [gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg] induces expression of the [gene|8C13E1EF5437DD8F9906643DEDCBB18DABE3B9E3|tapA]-[gene|09B082BF39703F0D9A5980E643175DBD59F5B228|sipW]-[gene|BF97457E986656E4A9FE7A858F5BDF1759850D5C|tasA] operon [Pubmed|23378512]
  • [protein|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|Veg] may inhibit the [protein|920F91E748EE079FF864011D9052B073567C41E4|SlrR]-[protein|5A6FBAE6553343092862CB79E150F934978C32A9|SinR] interaction [Pubmed|23378512]

    • Structure

  • [PDB|3FB9] (from Streptococcus pneumoniae, 34% identity)

    • [SW|Localization]

  • cytoplasm [pubmed|12761295]

    • Expression and Regulation

    Operons

    genes
    [gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]
    description
    [Pubmed|12761295]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|12761295], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulation

  • constitutively expressed [Pubmed|12761295]
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    Biological materials

    Mutant

  • GP2888 (Δ[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]::ermC trpC2) available in [SW|Jörg Stülke]'s lab
  • MGNA-B909 (veg::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1908 NBRP B. subtilis, Japan]
  • BKE00440 (Δ[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE00440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCATCCACCTCACTAC, downstream forward: _UP4_TAACGGGCAGTGAACCTTTT
  • BKK00440 (Δ[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK00440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCATCCACCTCACTAC, downstream forward: _UP4_TAACGGGCAGTGAACCTTTT

    • lacZ fusion

  • GP2898 ([gene|DE4857E8A228F145EFB9B7AD817585258344ED1F|amyE]::(Pveg-lacZ cat) trpC2) available in [SW|Jörg Stülke]'s lab

    • References

  • 12761295,23378512,23701187