purine nucleoside phosphorylase
function
purine salvage and interconversion
product
purine nucleoside phosphorylase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon]The protein
Catalyzed reaction/ biological activity
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate (according to Swiss-Prot) RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate (according to Swiss-Prot)Protein family
PNP/MTAP phosphorylase family (according to Swiss-Prot) polyribonucleotide nucleotidyltransferase family (according to Swiss-Prot)Modification
phosphorylation on Ser-28 [Pubmed|17218307][SW|Localization]
secreted (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|drm]-[protein|search|pupG]'' [Pubmed|10537218][SW|Sigma factor]
[protein|search|SigA] [Pubmed|10537218]Regulation
induced in the presence of nucleosides (deoxyribose 5-phosphate and ribose 5-phosphate act as molecular inducers) [Pubmed|10537218]subject to carbon catabolite repression ([protein|search|CcpA]) [Pubmed|22900538,10537218]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|22900538]References
10537218,22900538,17218307 
