two-component sensor kinase, regulation of phosphate metabolism
function
regulation of phosphate metabolism
product
two-component sensor kinase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|phosphate metabolism], [SW|protein modification], [SW|transcription factors and their control], [SW|sporulation proteins], [SW|general stress proteins (controlled by SigB)], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|PhoP regulon], [SW|SigB regulon], [SW|SigE regulon]The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|search|PhoP][SW|Domains]
two transmembrane segments[SW|PAS domain], for binding of an intermediate of wall teichoic acid biosynthesis [Pubmed|25315493]C-terminal histidine phosphotransferase domainModification
autophosphorylation on a His residue in response to the the availability of an intermediate of wall teichoic acid bioynthesis, autophosphorylation is prevented by binding of this intermediate to the intracellular [SW|PAS domain] of [protein|search|PhoR] [Pubmed|25315493]Effectors of protein activity
activity is inhibited by binding of an intermediate of wall teichoic acid biosynthesis to the intracellular [SW|PAS domain] of [protein|search|PhoR] [Pubmed|25315493]Structure
[PDB|3CWF] (extracellular domain) [Pubmed|20008068][SW|Interactions]
[protein|search|PhoP]-[protein|search|PhoR]Expression and Regulation
Operon
''[protein|search|phoP]-[protein|search|phoR]'' [Pubmed|14762014][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16452408], [protein|search|SigB] [Pubmed|15205429], [protein|search|SigE] [Pubmed|15699190,15205429]Regulation
carbon catabolite repression ([protein|search|CcpA]) [Pubmed|16452408]expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|25666134,15205429,14762014]expressed in post-exponential phase ([protein|search|ScoC]) [Pubmed|20382764]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|16452408,12850135][protein|search|PhoP]: transcription activation, due to [protein|search|PhoP]~P binding to the 3’end of the ''[protein|search|phoP]-[protein|search|phoR]'' operon [Pubmed|25666134,15205429,14762014][protein|search|ScoC]: transcription repression [Pubmed|20382764]Biological materials
Mutant
1A966 ( ''phoR''::''tet''), [Pubmed|14973033], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A966&Search=1A966 BGSC]Labs working on this gene/protein
[SW|Marion Hulett], University of Illinois at Chicago, USA [http://www.uic.edu/depts/bios/faculty/hulett/hulettm.shtml Homepage]References
Reviews
Original publications
20008068,10433720,15205429,9084179,17085571,9987123,10913081,16452408,20167622,15205429,14762014,20382764,25315493 
