SubtiBank SubtiBank
qoxC
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qoxC

cytochrome aa3 quinol oxidase (subunit III)
locus
BSU_38150
pI
6.24
mw
22.53 kDa
protein length
204 aa Sequence Blast
gene length
615 bp Sequence Blast
function
respiration
product
cytochrome aa3 quinol oxidase (subunit III)
essential
no
ec
1.10.3.-
synonyms
ipa-39d

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    3,914,691 → 3,915,305

    The protein

    Catalyzed reaction/ biological activity

  • 2 quinol + O2 --> 2 quinone + 2 H2O (according to UniProt)
  • Protein family

  • cytochrome c oxidase subunit 3 family (with [protein|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|CtaE], according to UniProt)
  • Structure

  • [PDB|1FFT] ([protein|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|QoxA]-[protein|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|QoxB]-[protein|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|QoxC] complex from ''E. coli'', 52% identity) [Pubmed|11017202]
  • [SW|Localization]

  • cell membrane (according to UniProt)
  • Expression and Regulation

    Operons

    genes
    [gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]-[gene|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|qoxB]-[gene|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]-[gene|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD]
    description
    [Pubmed|1316894]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]
  • [protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB]: mRNA binding, in [regulon|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB regulon]
  • regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • additional information

  • the presence of an iron-responsive element bound by [SW|CitB] between ''[SW|feuA]'' and ''[SW|feuB]'' suggests iron-dependent regulation by [SW|CitB] [Pubmed|10468622]
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    Biological materials

    Mutant

  • BKE38150 (Δ[gene|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE38150 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAACTCACGCCTCCTTAT, downstream forward: _UP4_GGTGTCTATCTCATGGGATTG
  • BKK38150 (Δ[gene|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK38150 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAACTCACGCCTCCTTAT, downstream forward: _UP4_GGTGTCTATCTCATGGGATTG
  • GP2579 (Δ[gene|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]::tet comIQ12L) (in DK1042) available at [SW|Jörg Stülke]'s lab
  • References

  • 11073895,1316894,20351111,10551842,11017202,27503613