SubtiBank SubtiBank
ydiP
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ydiP

similar to DNA-3-methyladenine glycosidase II
locus
BSU_06070
pI
6.43
mw
43.12 kDa
protein length
389 aa Sequence Blast
gene length
1170 bp Sequence Blast
function
BsuM DNA modification
product
unknown
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.4|DNA restriction/ modification]
  • [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.5|Prophage 3]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    656,528 → 657,697

    Phenotypes of a mutant

  • essential [Pubmed|12682299], mutation is only possible in a ''[gene|4BD4CFB10700907DF1BBF3C9CFACAF573588E85F|ydiR]'', ''[gene|A8C606348C8C6FC3BB9786C06C9BFE9D3519A041|ydiS]'', or ''[gene|D36B91B3C8EAFEB80A7395C62A50A5F80B8CC5C5|ydjA]'' background (''i. e.'', in the absence of the BsuM DNA restriction system) [Pubmed|11751814]

    • The protein

    Catalyzed reaction/ biological activity

  • 2'-deoxycytidine in DNA + S-adenosyl-L-methionine --> 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine

    • Protein family

  • [SW|Methyltransferase superfamily] (according to UniProt)
  • [SW|class I-like SAM-binding methyltransferase superfamily] (according to UniProt)

    • [SW|Domains]

  • SAM-dependent MTase C5-type domain (aa 1-299) (according to UniProt)

    • Structure

  • [PDB|1DCT] (from Haemophilus aegyptus, 26% identity) [pubmed|7606780]

    • Expression and Regulation

    Operons

    genes
    [gene|9EE25F97B2C6240E31BA1D5EEE9DA2D7940C9637|ydiO]-[gene|CEA337DD4C7DFC22247FDA7FA1E71356FB819C77|ydiP]
    description
    [Pubmed|11751814]

    regulatory mechanism

  • [protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|16267290], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]

    • regulation

  • induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]
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    References

  • 16267290,11751814,22092861,7606780