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yabM
may function in a previously observed alternate pathway for peptidoglycan strand synthesis
function
alternate pathway for peptidoglycan strand synthesis
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
64,817 → 66,415
Phenotypes of a mutant
Mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A [SW|penicillin-binding proteins] [Pubmed|19648239]The protein
Catalyzed reaction/ biological activity
may function in a previously observed alternate pathway for peptidoglycan strand synthesis [Pubmed|19648239]Protein family
[SW|Polysaccharide synthase family] (according to UniProt)[SW|MOP exporter family]Paralogous protein(s)
[protein|0AFFB4B715CCE6B1C53BBB7F890EFB3126CB466E|MurJ], [protein|34A5CD28A3DBCB10B4E1C82E50143FA73B553919|YkvU], [protein|9633C40190B7D0EA264270FD44567C61A012AD15|SpoVB] [SW|Localization]
cell membrane (according to UniProt)Expression and Regulation
Operons
genes
[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]-[gene|52D48F22CB53421EE30970D34B4861E2F8A5893D|yabN]-[gene|B0CB19A3E3E84E12BF42BB050394C8A059A89359|yabO]-[gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]-[gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|yabQ]-[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
description
[Pubmed|11283287]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM]: sigma factor, [Pubmed|18179421], in [regulon|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM regulon][protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|15699190,11283287], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon][protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|SigW]: sigma factor, [Pubmed|12207695], in [regulon|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|SigW regulon][protein|7024E4162A6D827069F882FDEACA696EBC05DD40|SigD]: sigma factor, [Pubmed|26577401], in [regulon|7024E4162A6D827069F882FDEACA696EBC05DD40|SigD regulon][protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|SigX]: sigma factor, [Pubmed|12207695], in [regulon|E77364F274A520FCCA9F5C9504E317B047BA29E6|SigX regulon]regulation
expressed during sporulation ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]) [Pubmed|11283287]view in new tabBiological materials
Mutant
MGNA-B914 (yabM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1913 NBRP B. subtilis, Japan]BKE00570 (Δ[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE00570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCAAAAGCTCCTTCCCA, downstream forward: _UP4_AAATTCATGAGAAGGAGAGABKK00570 (Δ[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK00570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCCAAAAGCTCCTTCCCA, downstream forward: _UP4_AAATTCATGAGAAGGAGAGAReferences
11283287,19648239,19666716