SubtiBank SubtiBank
spoIVB [Mon Aug 31 2015 13:55:31 GMT+0200 (CEST)]
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spoIVB [Mon Aug 31 2015 13:55:31 GMT+0200 (CEST)]

serine protease, cleaves SpoIVFA to prepare it for CtpB cleavage, this results in pro-SigK processing/activation in the mother-cell, does also cleave CtpB
locus
BSU24230
pI
8.84
mw
45.00 kDa
function
control of SigK activation
product
serine protease
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [SW|Categories] containing this gene/protein

  • [SW|sigma factors and their control], [SW|sporulation proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigF regulon], [SW|SigG regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB (according to Swiss-Prot)
  • Protein family

  • PDZ protease [Pubmed|24243021]
  • [SW|Localization]

  • intracellular space between the mother cell and the forespore [Pubmed|24243021]
  • [SW|Interactions]

  • [SW|SpoIVB]-[protein|search|BofA] [Pubmed|15292188]
  • [protein|search|BofC]-[SW|SpoIVB] [Pubmed|10931291]
  • [SW|SpoIVB]-[SW|SpoIVFA] [Pubmed|24243021]
  • Expression and Regulation

    Operon

  • ''spoIVB'' [Pubmed|2106508]
  • [SW|Sigma factor]

  • [protein|search|SigF] [Pubmed|15699190,9004507], [protein|search|SigG] [Pubmed|15699190,9004507]
  • Regulation

  • expressed during sporulation in the forespore ([protein|search|SigF], [protein|search|SigG], [SW|SpoVT]) [Pubmed|16497325,15699190,9004507,8755877]
  • Regulatory mechanism

  • [SW|SpoVT]: transcription activation [Pubmed|8755877]
  • Labs working on this gene/protein

  • Simon Cutting, London, UK [http://personal.rhul.ac.uk/uhba/009/bacillus/simon_cutting.html homepage]
  • References

  • 17493131,2106508,10931284,14526016,10931291,1900494,11418578,15292188,9004507,12940997,11741860,16497325,8755877,24243021,15292188,17557826,16818230