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21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.
serine protease, cleaves SpoIVFA to prepare it for CtpB cleavage, this results in pro-SigK processing/activation in the mother-cell, does also cleave CtpB
control of SigK activation
categories[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 220.127.116.11|Control of sigma factors][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 18.104.22.168|Sporulation proteins/ other]
[SW|Categories] containing this gene/protein[SW|sigma factors and their control], [SW|sporulation proteins]
This gene is a member of the following [SW|regulons][SW|SigF regulon], [SW|SigG regulon]
Catalyzed reaction/ biological activitySelf-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB (according to Swiss-Prot)
Protein familyPDZ protease [Pubmed|24243021]
[SW|Localization]intracellular space between the mother cell and the forespore [Pubmed|24243021]
[SW|Interactions][SW|SpoIVB]-[protein|search|BofA] [Pubmed|15292188][protein|search|BofC]-[SW|SpoIVB] [Pubmed|10931291][SW|SpoIVB]-[SW|SpoIVFA] [Pubmed|24243021]
Expression and Regulation
[SW|Sigma factor][protein|search|SigF] [Pubmed|15699190,9004507], [protein|search|SigG] [Pubmed|15699190,9004507]
Regulationexpressed during sporulation in the forespore ([protein|search|SigF], [protein|search|SigG], [SW|SpoVT]) [Pubmed|16497325,15699190,9004507,8755877]
Regulatory mechanism[SW|SpoVT]: transcription activation [Pubmed|8755877]
Labs working on this gene/proteinSimon Cutting, London, UK [http://personal.rhul.ac.uk/uhba/009/bacillus/simon_cutting.html homepage]