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secreted quality control protease
function
protein quality control
product
secreted quality control protease
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.1|Protein quality control][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]Gene
Coordinates
1,153,789 → 1,156,473
The protein
Catalyzed reaction/ biological activity
important for [protein|780FDF3DD260287428B397FFE7F44DDF1917381C|TatAY]-[protein|E60FC9C9B273DD6B07B7B95819525DE5F35113CE|TatCY]-dependent export of [protein|253A24EEA02C07E577A96FB64DF39F9A3D0C3A52|YkuE] and [protein|3985F88334D7B034A66473C5BB39188AB61A65F6|EfeB] [Pubmed|23180473]involved in degradation of [protein|6EE13E61A218A6D52BAC83A1145B0B96961CE289|PrsA], [protein|76FA52D5A5F9FCA14BA9B45872FE3D99D89B211B|HtrA], and [protein|796216BE9CD6DADFEADC29497253C81BF496A2ED|HtrB] [Pubmed|24362423]Protein family
[SW|peptidase S8 family] (according to UniProt)[SW|Domains]
[SW|peptidase S8 domain] (aa 422-729) (according to UniProt)Structure
[PDB|1DBI] (the peptidase S8 domain from Bacillus sp., aa 458 ... 687, 46% identity) [pubmed|10588904][SW|Localization]
extracellular (signal peptide) [Pubmed|18957862]membrane [Pubmed|18763711]cell wall [Pubmed|23180473]Expression and Regulation
Operons
genes
[gene|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|wprA]
description
[Pubmed|16306698]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|22900538], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|22900538], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon][protein|7098319D8E88FDC2A629A3F4A21507FD7A649385|YvrHb]: activation, [Pubmed|16306698], in [regulon|7098319D8E88FDC2A629A3F4A21507FD7A649385|YvrHb regulon]regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|22900538]additional information
An [ncRNA|search|antisense RNA] is predicted for'[protein|search|wprA]' [PubMed|20525796]view in new tabBiological materials
Mutant
1A1021 ( ''wprA''::''kan''), [Pubmed|20400548], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A1021&Search=1A1021 BGSC]BKE10770 (Δ[gene|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|wprA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10770 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTATCCCTCCTGCAAA, downstream forward: _UP4_TAACCAAAAAGCGGTGCTCGBKK10770 (Δ[gene|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|wprA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10770 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTATCCCTCCTGCAAA, downstream forward: _UP4_TAACCAAAAAGCGGTGCTCGReferences
Reviews
Original publications
22900538,22923395,23180473,21815947,10075409,11987133,9004506,20525796,18957862,18763711,16306698,9687444,12028417,24362423,24115457,10588904