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treR
transcription repressor of the [gene|BC568649A341B2E6341993EDA4BF52BDE18A3294|treP]-[gene|2EB9E0C492DF57DF683817E31D6DD34D7580E631|treA]-[gene|search|treR ]operon ([SW|GntR family])
function
regulation of trehalose utilization
product
transcription repressor ([SW|GntR family])
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.20|Utilization of trehalose][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]Gene
Coordinates
853,556 → 854,272
The protein
Protein family
[SW|GntR family] of transcription factors[SW|Domains]
[SW|HTH gntR-type domain] (aa 1-71) (according to UniProt)Structure
[PDB|2OGG] (effector binding domain) [Pubmed|17705272]additional information
information on binding sites can be found in the [http://www.prodoric2.de/detail.php?acc=MX000087 PRODORIC2 database]Expression and Regulation
Operons
genes
[gene|BC568649A341B2E6341993EDA4BF52BDE18A3294|treP]-[gene|2EB9E0C492DF57DF683817E31D6DD34D7580E631|treA]-[gene|DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|treR]
description
[Pubmed|8755887]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8755887], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|TreR]: repression, [Pubmed|8755887], in [regulon|DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|TreR regulon][protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|18977770], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon][protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]: activation, [Pubmed|21636651], in [regulon|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP regulon]regulation
expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|21636651]view in new tabBiological materials
Mutant
MGNA-C261 (treR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2259 NBRP B. subtilis, Japan]BKE07820 (Δ[gene|DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|treR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE07820 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATGGACCACCCAGCTT, downstream forward: _UP4_TGAGAGAGGCGCCTGCCTGCBKK07820 (Δ[gene|DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|treR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK07820 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATGGACCACCCAGCTT, downstream forward: _UP4_TGAGAGAGGCGCCTGCCTGCReferences
8755887,9829827,8917076,17705272,18977770