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ytaG

dephospho-CoA kinase

locus: BSU29060

pI: 4.86

mw: 21.87 kDa

protein length: 197 aa

gene length: 591 bp

function: synthesis of coenzyme A

product: dephospho-CoA kinase

essential: yes

ec: 2.7.1.24

synonyms: coaE

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue]

Gene

Coordinates: 2,970,922 → 2,971,515

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP + 3'-dephospho-CoA = ADP + CoA (according to Swiss-Prot)

Protein family

• coaE family (according to Swiss-Prot)

Modification

• phosphorylated on ser/ thr/ tyr [Pubmed|16493705]

Structure

• [PDB|1N3B] (from ''Escherichia coli'', 40% identity, 60% similarity) [Pubmed|12538896]

Expression and Regulation

Operons

• genes: [gene|3D6DA8B52A4CB49361E67906140696FFA1EF6099|polA]-[gene|EC96EDED2472607DFA4C5EBA054157F7832EE41C|mutM]-[gene|3BEE8E248BC583FCCB37B7A209A122DD93CD398C|ytaF]-[gene|E163A282560DB882B81E783E7E95E1960F4AE4D2|ytaG]
  description: [pubmed|22383849]

  sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|23396918], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]

• genes: [gene|E163A282560DB882B81E783E7E95E1960F4AE4D2|ytaG]
  description: [Pubmed|9387221]

Biological materials

Mutant

• MGNA-A118 (ytaG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/118 NBRP B. subtilis, Japan]

References

• 16493705,9387221,11292795,12538896