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yisP
farnesyl diphosphate phosphatase, production of farnesol
function
control of [protein|A656321846B2E0D1F39B528E2D8B8E620CCD1148|KinC] activity
product
farnesyl diphosphate phosphatase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay]Gene
Coordinates
1,159,922 → 1,160,746
Phenotypes of a mutant
complete loss of pellicle-forming ability [Pubmed|20713508]reduced [SW|protein secretion] [Pubmed|23651456]The protein
Catalyzed reaction/ biological activity
farnesyl diphosphate -→ farnesol [Pubmed|25308276]Protein family
phytoene/squalene synthase family (single member, according to UniProt)[SW|Cofactors]
NADH [Pubmed|20713508]Structure
[PDB|3WE9] [Pubmed|25308276]Expression and Regulation
Operons
genes
[gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP]
description
[pubmed|22383849]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|26577401], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]view in new tabBiological materials
Mutant
MGNA-B190 (yisP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1189 NBRP B. subtilis, Japan]BKE10810 (Δ[gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGCTTCTTCAAGTCTAG, downstream forward: _UP4_TAAAAAACACCCGGCCTTGABKK10810 (Δ[gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGCTTCTTCAAGTCTAG, downstream forward: _UP4_TAAAAAACACCCGGCCTTGAReferences
Reviews
Original publications
20713508,19935659,23651456,23295493,25308276,26577401