yisP [2017-8-11 16:0:3]

farnesyl diphosphate phosphatase, production of farnesol

locus: BSU10810

pI: 7.26

mw: 31.35 kDa

protein length: 274 aa

gene length: 822 bp

function: control of KinC activity

product: farnesyl diphosphate phosphatase

essential: no

synonyms: yucD

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay]

Gene

Coordinates: 1,159,922 → 1,160,746

Phenotypes of a mutant

• complete loss of pellicle-forming ability [Pubmed|20713508]
• reduced [SW|protein secretion] [Pubmed|23651456]

The protein

Catalyzed reaction/ biological activity

• farnesyl diphosphate -→ farnesol [Pubmed|25308276]

[SW|Cofactors]

• NADH [Pubmed|20713508]

Structure

• [PDB|3WE9] [Pubmed|25308276]

Expression and Regulation

Operons

• genes: [gene|E5F32D960F6FF50A7B0E4B268D2296FE1A291512|yisP]
  description: [pubmed|22383849]

  sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|26577401], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

Biological materials

Mutant

• MGNA-B190 (yisP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1189 NBRP B. subtilis, Japan]

References

Reviews

• 25457121,25652542

Original publications

• 20713508,19935659,23651456,23295493,25308276,26577401