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transcriptional repressor of the dra-nupC-pdp operon
function
regulation of deoxyribonucleotide utilization
product
transcriptional repressor
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.1|Utilization of nucleotides][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]Gene
Coordinates
4,052,379 → 4,053,320
The protein
Catalyzed reaction/ biological activity
transcription repression of the ''[gene|81CD1F97E887549F7FB742FCEF38B86B84383F5D|dra]-[gene|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC]-[gene|D2EB7BBAC8817912DAC4E215879F5A4E2C47ECAF|pdp]'' operonProtein family
SorC transcriptional regulatory family (with [protein|ADA6F2EDC7B18FDFFA47CC8C55BCDDE1B6821160|CggR], according to UniProt)[SW|Domains]
N-terminal DNA-binding domain [Pubmed|24863636]C-terminal effector binding domain [Pubmed|24863636]Effectors of protein activity
deoxyribose-5-phosphate acts as the molecular inducer [Pubmed|24863636]Structure
[PDB|4OQQ] (C-terminal effector binding domain) [Pubmed|24863636][http://pdb.org/pdb/explore/explore.do?structureId=4OQP 4OQP] (C-terminal effector binding domain bound to the effector deoxyribose-5-phosphate ) [Pubmed|24863636]Expression and Regulation
Operons
genes
[gene|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]
description
[Pubmed|10746760]
view in new tabBiological materials
Mutant
BKE39430 (Δ[gene|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE39430 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTGCACCTCCCTGTGG, downstream forward: _UP4_TGACACGTTCAAACCTTTCABKK39430 (Δ[gene|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK39430 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTGCACCTCCCTGTGG, downstream forward: _UP4_TGACACGTTCAAACCTTTCAReferences
10714997,8550462,10074062,24863636