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zapA [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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zapA [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

positive modulator of FtsZ Z ring assembly and stability
locus
BSU28610
pI
7.00
mw
9.00 kDa
function
control of Z-ring formation
product
Z-ring-associated protein
essential
no
synonyms
yshA

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
  • [SW|Categories] containing this gene/protein

  • [SW|cell division], [SW|membrane proteins]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,925,640 -> 2,925,897

    Phenotypes of a mutant

  • a ''[protein|search|zapA] [protein|search|ezrA]'' double mutant forms filamentous cells [Pubmed|16420366]
  • a ''[protein|search|yvcL] [protein|search|zapA]'' double mutant grows poorly, and the cells are filamentous (due to a defect in Z ring assembly) [Pubmed|24097947]
  • the defects of the ''[protein|search|yvcL] [protein|search|zapA]'' double mutant can be suppressed by inactivation of either ''[protein|search|gtaB]'', ''[protein|search|pgcA]'', or ''[protein|search|ugtP]'' [Pubmed|24097947]
  • The protein

    Protein family

  • Type 2 subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|1W2E] (from ''Pseudomonas aeruginosa'') [Pubmed|15288790]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • [SW|Interactions]

  • forms a tetramer [Pubmed|23098212]
  • [protein|search|FtsZ]-[protein|search|ZapA] [Pubmed|19843223]
  • Expression and Regulation

    Operon

  • ''[protein|search|zapA]-[protein|search|yshB]'' [Pubmed|12368265]
  • Regulation

  • constitutively expressed [Pubmed|23701187]
  • References

    Reviews

  • 19680248,19884039,23701187
  • Original Publications

  • 15288790,12368265,16420366,18588879,19429628,19843223,24097947,23098212