nitric oxide-responsive regulator
function
repression of ResD-ResE-dependent genes in the absence of nitric oxide (NO)
product
transcriptional repressor
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.10|Resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)]Gene
Coordinates on the chromosome (coding sequence)
1,013,411 -> 1,013,851
The protein
[SW|Cofactors]
[4Fe-4S] cluster, required for DNA-binding [Pubmed|21091510]Effectors of protein activity
nitric oxide (NO) acts as molecular inducer and results in NsrR release from its DNA targets [Pubmed|19006327][4Fe-4S]-NsrR binds around the -35 element of the ''[protein|search|nasD]'' promoter with much higher affinity than apo-NsrR and binding of [4Fe-4S]-NsrR, but not apo-protein, is sensitive to NO [Pubmed|21091510]Expression and Regulation
Operon
''nsrR'' [Pubmed|10322020]References
Reviews
23046954,16261196,20167493 The [SW|NsrR regulon]
Other original publications
16885456,24214949,17293416,21091510,19006327,18989365 
