glpT [Mon Aug 31 2015 13:52:07 GMT+0200 (CEST)]

glycerol-3-phosphate permease

locus: BSU02140

pI: 9.37

mw: 49.00 kDa

function: glycerol-3-phosphate uptake

product: glycerol-3-phosphate permease

essential: no

synonyms: ybeE

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.3|Carbohydrate transporter]
• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.3|Utilization of glycerol/ glycerol-3-phosphate]
• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.1|Utilization of phospholipids]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

syns: ybeE

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|utilization of specific carbon sources], [SW|utilization of lipids], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|GlpP regulon]

The protein

Protein family

• SLC37A family (according to Swiss-Prot)

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|glpT]-[protein|search|glpQ]'' [Pubmed|8012593]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8012593]

Regulation

• repressed by glucose (6.2-fold) ([protein|search|CcpA]) [Pubmed|12850135]
• induced by glycerol ([protein|search|GlpP]) [Pubmed|8012593]

Regulatory mechanism

• [protein|search|CcpA]: transcription repression
• [protein|search|GlpP]: transcriptional antitermination ''via'' a protein-dependent [SW|RNA switch] [Pubmed|8012593]

Biological materials

Mutant

• QB5437 (ermC), available in the [SW|Stülke] lab

References

• 8012593,12850135