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hutU
function
histidine utilization
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.5|Utilization of histidine]Gene
Coordinates
4,043,574 → 4,045,232
The protein
Catalyzed reaction/ biological activity
4-imidazolone-5-propanoate --> H2O + trans-urocanate (according to UniProt)Protein family
urocanase family (single member, according to UniProt)Structure
[PDB|2FKN][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|hutP]-[gene|DB0FDF43A6829692D3E6B9CDE9D0F4AA1E3EB888|hutH]-[gene|ED6002BB56B96F9A2B4F80CA050518B266000E55|hutU]-[gene|BD3382760B704972A0E67ECEDA4B29AA4ECD8164|hutI]-[gene|FBB15E07B7134C57208EA82D5339708385DBC5FB|hutG]-[gene|423AEC9D260BE53AD22851D999244B89BEB3E84D|hutM]
description
[Pubmed|10746760]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8071225], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|8071225], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon][protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|8682780], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon][protein|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|HutP]: antitermination, at a protein-dependent [SW|RNA switch] located between [gene|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|hutP] and [gene|DB0FDF43A6829692D3E6B9CDE9D0F4AA1E3EB888|hutH] [Pubmed|8071225], in [regulon|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|HutP regulon]regulation
induced by histidine ([protein|search|HutP]) [Pubmed|8071225]view in new tabBiological materials
Mutant
BKE39360 (Δ[gene|ED6002BB56B96F9A2B4F80CA050518B266000E55|hutU]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE39360 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGTCATATGTTCATCCCCCT, downstream forward: _UP4_ATGCAAAAATAAAGGAGTGABKK39360 (Δ[gene|ED6002BB56B96F9A2B4F80CA050518B266000E55|hutU]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK39360 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGTCATATGTTCATCCCCCT, downstream forward: _UP4_ATGCAAAAATAAAGGAGTGAReferences
Reviews
Original publications
10746760,8071225,8682780,10217782,21821766