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gerKA
function
germination response to the combination of glucose, fructose, aspartate, and KCl
product
nutrient receptor
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.4|Germination] → [category|SW 4.2.4.1|Germinant receptors][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
420,110 → 421,744
The protein
Protein family
[SW|GerABKA family] (according to UniProt)Paralogous protein(s)
[protein|EEDE6A22E91992ABCA677CAB7917B7168C5CB868|GerAA], [protein|AE28299B0F274B189DD90554A5A4F7B9A9479B60|YndD], [protein|3368743E6E03792DB83A38A19989123304DF7560|GerBA], [protein|7CE0CAF27B1C0F507E783B8B80622270B00634FD|YfkQ] [SW|Domains]
contains multiple membrane-spanning domains [Pubmed|23335419]Structure
[PDB|6O59] (from B. megaterium, corresponds to aa 40 ... 299, 53.6% identity) [pubmed|31113879][SW|Localization]
outer surface of the inner spore membrane [Pubmed|23335419,21696470]Additional information
700 molecules are present per spore [Pubmed|23749970]Expression and Regulation
Operons
genes
[gene|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]-[gene|D5D4E1E182F972BEF6BB432A7FF25EF45F1F0D95|gerKC]-[gene|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]
description
[pubmed|22383849]
sigma factors
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG]: sigma factor, [Pubmed|16707705], in [regulon|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG regulon]regulatory mechanism
[protein|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|SpoVT]: repression, [Pubmed|16707705], in [regulon|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|SpoVT regulon]regulation
expressed during sporulation ([protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG], [SW|SpoVT]) [Pubmed|16707705]additional information
700 molecules are present per spore [PubMed|23749970]view in new tabBiological materials
Mutant
BKE03700 (Δ[gene|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE03700 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACACAAATACCTTTCCT, downstream forward: _UP4_AAAGATTTGGAAGAAGGGGABKK03700 (Δ[gene|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK03700 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACACAAATACCTTTCCT, downstream forward: _UP4_AAAGATTTGGAAGAAGGGGAReferences
16707705,16352818,21696470,23335419,23396907,22343299,16740944,23749970,24752279,26731423,31113879