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narK
nitrite extrusion protein
function
nitrate respiration, nitrite export
product
nitrite extrusion protein
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.11|Other exporters][category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.2|Anaerobic respiration][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,832,327 → 3,833,514
The protein
Protein family
[SW|major facilitator superfamily] (according to UniProt)Nitrate/nitrite porter (TC 2.A.1.8) family (with [protein|2DE7BEC614129384779F4C761E0792385DECC563|NasA], according to UniProt)Paralogous protein(s)
[protein|2DE7BEC614129384779F4C761E0792385DECC563|NasA] Structure
[PDB|4JR9] (from E. coli, 25% identity) [pubmed|23665960][SW|Localization]
cell membrane [Pubmed|18763711]Expression and Regulation
Operons
genes
[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]-[gene|7165CC59CDAF64AAE2D591936860304A53BE5DF6|fnr]
description
[Pubmed|8846791]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8846791], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|EC6697D5D945B7E5083AFED9218748763C443278|NsrR]: repression, [Pubmed|16885456], in [regulon|EC6697D5D945B7E5083AFED9218748763C443278|NsrR regulon][protein|7165CC59CDAF64AAE2D591936860304A53BE5DF6|Fnr]: activation, [Pubmed|8846791,16428414], in [regulon|7165CC59CDAF64AAE2D591936860304A53BE5DF6|Fnr regulon]regulation
''[protein|search|fnr]'': expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972836]view in new tabBiological materials
Mutant
BKE37320 (Δ[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE37320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGGCTTGCCCCTTTCA, downstream forward: _UP4_TAACACTGGGGCATTCACAABKK37320 (Δ[gene|F14481DAA196868ACC1DE9EC8CBE593A2CBB6BE4|narK]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK37320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGGCTTGCCCCTTTCA, downstream forward: _UP4_TAACACTGGGGCATTCACAAReferences
Reviews
Original publications
16885456,8846791,16428414,18763711,23665960