manR [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

transcriptional activator of the manP-manA-yjdF operon

locus: BSU12000

pI: 8.00

mw: 75.00 kDa

function: regulation of mannose utilization

product: transcriptional activator, PRD-type

essential: no

synonyms: yjdC

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.9|Utilization of mannose]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.3|PRD-type regulators]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources], [SW|transcription factors and their control], [SW|phosphoproteins]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|ManR regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,270,631 -> 1,272,577

The protein

Modification

• phosphorylation by [protein|search|ManP] inactivates [protein|search|ManR] (in the absence of mannose), phosphorylation by [ptsH|search|HPr] stimluates [protein|search|ManR] [Pubmed|20139185]

[SW|Interactions]

• [protein|search|ManP]-[protein|search|ManR] [Pubmed|20139185]
• [ptsH|search|HPr]-[protein|search|ManR] [Pubmed|20139185]

Expression and Regulation

Operon

• ''[protein|search|manR]'' [Pubmed|20139185]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|20139185]

Regulation

• induced by mannose ([protein|search|ManR]) [Pubmed|20139185]
• repressed by glucose ([protein|search|CcpA], [protein|search|ManR]) [Pubmed|22900538,20139185]

Regulatory mechanism

• [protein|search|ManR]: transcription activation in the presence of mannose and absence of glucose [Pubmed|20139185]
• [protein|search|CcpA]: transcription repression [Pubmed|22900538]

Biological materials

Mutant

• MGNA-A269 (yjdC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/269 NBRP B. subtilis, Japan]

References

• 10627040,20139185,9663674,20139185,22900538,23551403