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manR [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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manR [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

transcriptional activator of the manP-manA-yjdF operon
locus
BSU12000
pI
8.04
mw
75.00 kDa
function
regulation of mannose utilization
product
transcriptional activator, PRD-type
essential
no
synonyms
yjdC

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.9|Utilization of mannose]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.3|PRD-type regulators]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]
  • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources], [SW|transcription factors and their control], [SW|phosphoproteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|ManR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,270,631 -> 1,272,577

    The protein

    Modification

  • phosphorylation by [protein|search|ManP] inactivates [protein|search|ManR] (in the absence of mannose), phosphorylation by [ptsH|search|HPr] stimluates [protein|search|ManR] [Pubmed|20139185]
  • [SW|Interactions]

  • [protein|search|ManP]-[protein|search|ManR] [Pubmed|20139185]
  • [ptsH|search|HPr]-[protein|search|ManR] [Pubmed|20139185]
  • Expression and Regulation

    Operon

  • ''[protein|search|manR]'' [Pubmed|20139185]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|20139185]
  • Regulation

  • induced by mannose ([protein|search|ManR]) [Pubmed|20139185]
  • repressed by glucose ([protein|search|CcpA], [protein|search|ManR]) [Pubmed|22900538,20139185]
  • Regulatory mechanism

  • [protein|search|ManR]: transcription activation in the presence of mannose and absence of glucose [Pubmed|20139185]
  • [protein|search|CcpA]: transcription repression [Pubmed|22900538]
  • References

  • 10627040,20139185,9663674,20139185,22900538,23551403