SubtiBank SubtiBank
sul
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sul

dihydropteroate synthase
locus
BSU_00770
pI
5.36
mw
30.85 kDa
protein length
285 aa Sequence Blast
gene length
858 bp Sequence Blast
function
biosynthesis of folate
product
dihydropteroate synthase
essential
yes
ec
2.5.1.15
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    85,737 → 86,594

    Phenotypes of a mutant

  • essential [Pubmed|28189581]

    • The protein

    Catalyzed reaction/ biological activity

  • (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate --> diphosphate + dihydropteroate (according to UniProt)

    • Protein family

  • DHPS family (single member, according to UniProt)

    • [SW|Domains]

  • Pterin-binding domain (aa 25-271) (according to UniProt)

    • Structure

  • [PDB|1AJZ] (from ''Escherichia coli'', 43% identity, 61% similarity) [Pubmed|9187658]

    • [SW|Localization]

  • cytoplasm (according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|B189AD3E3D18876E1956763182D835A151727392|pabB]-[gene|956E33AAAADB302EB8663E4B75C917242D3AD2C0|pabA]-[gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]-[gene|FA9539CB701BC47FD4E849FBA6D7B201B27C6104|sul]-[gene|AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787|folB]-[gene|D2B189C6292ACE1B25658B407C284E9A683EAE5B|folK]-[gene|F373EBC35805DC551E8AFF6FDC7E43D5587C4700|yazB]-[gene|CE45D56BC413555AF4E7914B5307AD967A358452|yacF]-[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]
    description
    [Pubmed|9084182]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9084182], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulation

  • translation repressed by tryptophan ([protein|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|MtrB]) [Pubmed|9084182]
    • view in new tab

    References

  • 9084182,28189581