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hutG
formiminoglutamate hydrolase
function
histidine utilization
product
formiminoglutamate hydrolase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.5|Utilization of histidine]Gene
Coordinates
4,046,503 → 4,047,462
The protein
Catalyzed reaction/ biological activity
H2O + N-formimidoyl-L-glutamate --> formamide + L-glutamate (according to UniProt)Protein family
arginase family (with [protein|CD121BBF1DC206D1189ECF8B32456641A55C41D4|RocF] and [protein|EA0AA0ECBC4A36A3F01F5876900FE51243D9AD07|SpeB], according to UniProt)Structure
[PDB|3M1R]Expression and Regulation
Operons
genes
[gene|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|hutP]-[gene|DB0FDF43A6829692D3E6B9CDE9D0F4AA1E3EB888|hutH]-[gene|ED6002BB56B96F9A2B4F80CA050518B266000E55|hutU]-[gene|BD3382760B704972A0E67ECEDA4B29AA4ECD8164|hutI]-[gene|FBB15E07B7134C57208EA82D5339708385DBC5FB|hutG]-[gene|423AEC9D260BE53AD22851D999244B89BEB3E84D|hutM]
description
[Pubmed|10746760]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8071225], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|8071225], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon][protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|8682780], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon][protein|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|HutP]: antitermination, at a protein-dependent [SW|RNA switch] located between [gene|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|hutP] and [gene|DB0FDF43A6829692D3E6B9CDE9D0F4AA1E3EB888|hutH] [Pubmed|8071225], in [regulon|BCA2700F27CA7A0C3FC08AAEBE615A783A42F408|HutP regulon]regulation
induced by histidine ([protein|search|HutP]) [Pubmed|8071225]view in new tabBiological materials
Mutant
BKE39380 (Δ[gene|FBB15E07B7134C57208EA82D5339708385DBC5FB|hutG]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE39380 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCCGGCCTCTCTGAGAAAAG, downstream forward: _UP4_TGATCTTCTGGCAGGTTGTABKK39380 (Δ[gene|FBB15E07B7134C57208EA82D5339708385DBC5FB|hutG]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK39380 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCCGGCCTCTCTGAGAAAAG, downstream forward: _UP4_TGATCTTCTGGCAGGTTGTAReferences
Reviews
Original publications
10746760,8682780,10217782,8071225