SubtiBank SubtiBank
sr1

sr1

small regulatory RNA controlling AhrC expression, regulatory peptide
locus
BSU14629
pI
4.00
mw
4.00 kDa
protein length
gene length
function
control of arginine metabolism and glycolysis
product
small regulatory RNA, regulatory peptide
essential
no
synonyms
ykzW, sr1

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.4|Utilization of arginine/ ornithine]
  • [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA]
  • [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.5|Regulatory RNAs]
  • Gene

    Coordinates
    1,534,120 → 1,534,239

    The peptide

    Catalyzed reaction/ biological activity:

  • the peptide controls the stability of the ''[gene|ADA6F2EDC7B18FDFFA47CC8C55BCDDE1B6821160|cggR]-[gene|EB6512177418B1601C6641FB2DEE99C2CD10E671|gapA]'' mRNA [Pubmed|20444087]
  • Protein family:

  • the peptide is conserved in bacilli
  • [SW|Interactions]:

  • [protein|EB6512177418B1601C6641FB2DEE99C2CD10E671|GapA]-[protein|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A|Sr1] [Pubmed|20444087]
  • The RNA

    Catalyzed reaction/ biological activity

  • hybridizes to ''[gene|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|ahrC]'' mRNA and inhibits [protein|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|AhrC] translation [Pubmed|17020585]
  • [SW|Interactions]

  • [gene|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|ahrC] mRNA-[gene|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A|sr1] RNA [Pubmed|20444087]
  • Additional information

  • Information on the structure of the RNA can be found in [Pubmed|17020585]
  • Database entries

    BsubCyc
    [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14629&redirect=T BSU14629]
    UniProt
    [http://www.uniprot.org/uniprot/C0H410 C0H410]

    Expression and Regulation

    Operons

    genes
    [gene|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A|sr1]
    description
    [Pubmed|16164558]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|16164558], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|CcpN]: repression, in [regulon|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|CcpN regulon]
  • regulation

  • Repressed in the presence of glucose by [protein|search|CcpN] [Pubmed|16164558]
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    Biological materials

    Mutant

  • 168 ykzW::cat, available in [SW|Sabine Brantl]'s lab
  • GP2210 (''[gene|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A|sr1]''::''cat''), available in [SW|Jörg Stülke]'s lab
  • GP2215 (''[gene|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A|sr1]''::''aphA3''), available in [SW|Jörg Stülke]'s lab
  • GP2216 (''[gene|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A|sr1]''::''phleo''), available in [SW|Jörg Stülke]'s lab
  • Labs working on this gene/protein

  • [SW|Sabine Brantl], Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany [http://www.uni-jena.de/AG_Bakteriengenetik_(_Doz__Dr__Sabine_Brantl_).html homepage]
  • References

    Reviews

  • 27750368
  • Original Publications

  • 16164558,17020585,17576690,20444087,23034808,27449348