divIC [Mon Aug 31 2015 13:51:49 GMT+0200 (CEST)]

cell-division initiation protein (septum formation), component of septosome (with DivIB)

locus: BSU00620

pI: 9.97

mw: 14.00 kDa

function: septum formation

product: cell-division protein

essential: yes

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|cell division], [SW|sporulation proteins], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigE regulon], [SW|SigM regulon], [SW|SigW regulon], [SW|SigX regulon]

Gene

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• stabilizes [protein|search|FtsL] against [protein|search|RasP] cleavage [Pubmed|20644139]

[SW|Localization]

• membrane bound [Pubmed|9426141]

[SW|Interactions]

• [SW|DivIC]-[protein|search|FtsL] [Pubmed|10844672]
• [protein|search|PbpB]-[SW|DivIB]-([protein|search|FtsL]-[SW|DivIC])2 [Pubmed|20870765], as part of the [SW|divisome]

Expression and Regulation

Operon

• ''[protein|search|yabM]-[protein|search|yabN]-[protein|search|yabO]-[protein|search|yabP]-[protein|search|yabQ]-[SW|divIC]-[protein|search|yabR]'' [Pubmed|11283287]
• ''[protein|search|yabP]-[protein|search|yabQ]-[SW|divIC]-[protein|search|yabR]'' [Pubmed|11283287]
• ''[SW|divIC]-[protein|search|yabR]'' [Pubmed|11283287]

[SW|Sigma factor]

• ''[protein|search|yabM]'': unknown
• ''[protein|search|yabP]'': [protein|search|SigE] [Pubmed|11283287]
• ''[SW|divIC]'': [protein|search|SigM] [Pubmed|18179421], [protein|search|SigX] [Pubmed|12207695], [protein|search|SigW] [Pubmed|12207695]

Regulation

• expressed during sporulation ([protein|search|SigE]) [Pubmed|11283287] and under stress conditions

Biological materials

FLAG-tag construct

• GP2006 ''divIC-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s lab

References

• 18179421,16936019,10217758,9720875,8113187,10323866,9426141,10852898,10844672,11283287,11994149,20870765,25176632,20644139