SubtiBank SubtiBank
yknY
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yknY

[SW|ABC transporter ](ATP-binding protein, exporter) for the export of the [protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|SdpC] toxin
locus
BSU_14360
pI
5.82
mw
25.12 kDa
protein length
230 aa Sequence Blast
gene length
693 bp Sequence Blast
function
resistance to [protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|SdpC] toxin
product
[SW|ABC transporter ](ATP-binding protein, exporter)
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    1,505,416 → 1,506,108

    The protein

    Protein family

  • [SW|ABC transporter superfamily] (according to UniProt)
  • Paralogous protein(s)

  • [protein|4FE6A51A0D9BBBF574EA2EF18B95B5BFC0A64CCB|YtrE], [protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|FtsE], [protein|8B4267532B9788AEB5EF39E2695C1FDA494C7055|YxdL], [protein|464DD1855E6B3195EE242637612A16C73FF32FC0|PsdA], [protein|8E0DE8FE7E9C12495C4DCADA74D838FED088867D|BceA], [protein|0F8048267EC038D8CF673317D969BA27735473A7|YvrO]
  • [SW|Domains]

  • [SW|ABC transporter domain] (aa 2-230) (according to UniProt)
  • Structure

  • [PDB|1L2T] (from Methanocaldococcus jannaschii, 52% identity) [pubmed|12150914]
  • [SW|Localization]

  • membrane associated (via [protein|9680326BAA94A503E2A5C6F0A2479AE0B0467B4C|YknZ]) [Pubmed|10092453]
  • Expression and Regulation

    Operons

    genes
    [gene|70D7098BEBD5E53B4B9B8C3394FAAF972C65EE22|yknU]-[gene|C6B0ACB9D9703DD8141FD7D9D62DB22FB48F458B|yknV]-[gene|916419C4ED113778488EBC558A35810498028B02|yknW]-[gene|FD270195901B89DAAAD134DB9DE729670A9BDECF|yknX]-[gene|FE3A01BEA974C5E32C68DC600C800E5EF101B34F|yknY]-[gene|9680326BAA94A503E2A5C6F0A2479AE0B0467B4C|yknZ]
    description
    [Pubmed|22383849]
    view in new tab

    genes
    [gene|916419C4ED113778488EBC558A35810498028B02|yknW]-[gene|FD270195901B89DAAAD134DB9DE729670A9BDECF|yknX]-[gene|FE3A01BEA974C5E32C68DC600C800E5EF101B34F|yknY]-[gene|9680326BAA94A503E2A5C6F0A2479AE0B0467B4C|yknZ]
    description
    [Pubmed|9987136]

    sigma factors

  • [protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|SigW]: sigma factor, [Pubmed|9987136], in [regulon|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|SigW regulon]
  • regulatory mechanism

  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|12076816], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]
  • regulation

  • repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|12076816]
  • view in new tab

    Biological materials

    Mutant

  • MGNA-B350 (yknY::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1349 NBRP B. subtilis, Japan]
  • BKE14360 (Δ[gene|FE3A01BEA974C5E32C68DC600C800E5EF101B34F|yknY]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14360 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCGCACATTAGAAAGCTGAA, downstream forward: _UP4_TCCGGACAAAGGAGTGTGGG
  • BKK14360 (Δ[gene|FE3A01BEA974C5E32C68DC600C800E5EF101B34F|yknY]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14360 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCGCACATTAGAAAGCTGAA, downstream forward: _UP4_TCCGGACAAAGGAGTGTGGG
  • References

  • 10092453,16629676,9987136,12076816,12150914