copZ
168
copper transport protein, metallochaperone
locus
BSU_33510
Molecular weight
7.20 kDa
pI
4.16
function
resistance to copper
product
copper transport protein, metallochaperone
essential
no
synonyms
copZ, yvgY
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2608 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,443,613 3,443,822
The protein
Catalyzed reaction/ biological activity
transfers Cu(I) to [protein|727024F7B1AC19676ED4B516CF46A47B1328310B|copA] [Pubmed|28078344]
[wiki|Domains]
HMA domain (aa 3-69) (according to UniProt)
[wiki|Cofactors]
carries a tetranuclear Cu(I) cluster (as [Cu4(S-Cys)4(N-His)2] cluster) [Pubmed|19746989]
Structure
[PDB|2QIF]
[AF|O32221]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|6977F18870004AD236539D9409255815E6BE9241|csoR]-[gene|18506FB74F6BB9278F22EB7DCDA3CF72575CC32A|copZ]-[gene|727024F7B1AC19676ED4B516CF46A47B1328310B|copA]
description
[Pubmed|22383849]
genes
[gene|18506FB74F6BB9278F22EB7DCDA3CF72575CC32A|copZ]-[gene|727024F7B1AC19676ED4B516CF46A47B1328310B|copA]
description
[Pubmed|12779235]
regulation
induced by copper ([protein|search|CsoR]) [Pubmed|18048925,12779235]
regulatory mechanism
[protein|6977F18870004AD236539D9409255815E6BE9241|csoR]: repression, [Pubmed|18048925], in [regulon|protein:6977F18870004AD236539D9409255815E6BE9241|csoR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|12779235], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE33510 ([gene|18506FB74F6BB9278F22EB7DCDA3CF72575CC32A|copZ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCAATTCCTCCTGTTT, downstream forward: _UP4_TGATTCAAGGTATCGCGCCT
BKK33510 ([gene|18506FB74F6BB9278F22EB7DCDA3CF72575CC32A|copZ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCAATTCCTCCTGTTT, downstream forward: _UP4_TGATTCAAGGTATCGCGCCT
labs
[wiki|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]
References
Reviews
Original Publications
Page visits: 4850
Time of last update: 2025-07-16 12:45:49
Author of last update: Melvin.boenninger