frlM

frlM
168

aminosugar [wiki|ABC transporter] (permease)

locus
BSU_32580
Molecular weight
34.00 kDa
pI
7
Protein length
Gene length
function
uptake of sugar amines
product
aminosugar [wiki|ABC transporter] (permease)
essential
no
synonyms
frlM, yurM

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0395

This gene is a member of the following regulons

Gene
Coordinates
3,347,919  3,348,821
The protein
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
[wiki|MalFG subfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transmembrane type-1 domain] (aa 94-285) (according to UniProt)
Structure
[PDB|2R6G] (from E. coli, corresponds to aa 96 ... 300, 36% identity) [pubmed|18033289]
[AF|O32154]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|C87E74FB67B53DD1C68916AA121388C60CE66E92|frlB]-[gene|9E3FF9D0B33D7EFEA3B61FF863BB46CC6DFD4F9B|frlO]-[gene|8256CAAEC591E40A8CB172FF053E03BFFD5A4B54|frlN]-[gene|1F245030D0C81DC96FC0642199CA00579CF46D06|frlM]-[gene|C3823AFED3E5C3D1EA04C38D861239468C9E6349|frlD]-[gene|3B9331D6755B8253944AB33521BBF2B3EBA4CAEB|frlP]
description
[Pubmed|23175651,21347729,22383849]
regulation
'' [protein|C87E74FB67B53DD1C68916AA121388C60CE66E92|frlB]'': repressed during growth in the presence of branched chain amino acids ([protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]) [Pubmed|12618455]
induced in the absence of [protein|F4097349A563503468A2A14F062AEAC532C7917A|ylxR] [pubmed|30355672]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [pubmed|12618455], [pubmed|18083814], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
[protein|412A1DBBE7F87765DEBEEAAE02A047636A354D5E|frlR]: repression, [Pubmed|21398478], in [regulon|protein:412A1DBBE7F87765DEBEEAAE02A047636A354D5E|frlR regulon]
[protein|F4097349A563503468A2A14F062AEAC532C7917A|ylxR]: unknown, [pubmed|30355672], in [regulon|protein:F4097349A563503468A2A14F062AEAC532C7917A|ylxR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [pubmed|22383849], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the [gene|C87E74FB67B53DD1C68916AA121388C60CE66E92|frlB]-[gene|9E3FF9D0B33D7EFEA3B61FF863BB46CC6DFD4F9B|frlO]-[gene|8256CAAEC591E40A8CB172FF053E03BFFD5A4B54|frlN]-[gene|1F245030D0C81DC96FC0642199CA00579CF46D06|frlM]-[gene|C3823AFED3E5C3D1EA04C38D861239468C9E6349|frlD]-[gene|3B9331D6755B8253944AB33521BBF2B3EBA4CAEB|frlP] operon is strongly downregulated in a [gene|search|cshA ]mutant [Pubmed|23175651]
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[gene|C87E74FB67B53DD1C68916AA121388C60CE66E92|frlB]→[gene|3B9331D6755B8253944AB33521BBF2B3EBA4CAEB|frlP]

2022-11-26 22:29:58

Jstuelk

35

1386d0b18bc93ba0b08e1c36531a0379aa199ac3

218EAE44649CE3CDE2633AF97E4CC56ABC5AA2E3

Biological materials
Mutant
MGNA-A559 (yurM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/559 NBRP B. subtilis, Japan]
BKE32580 ([gene|1F245030D0C81DC96FC0642199CA00579CF46D06|frlM]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32580 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGTCTTCTTCTGAGGCAGCA,  downstream forward: _UP4_GTAAAAGGATAAAGGAGGAA
BKK32580 ([gene|1F245030D0C81DC96FC0642199CA00579CF46D06|frlM]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32580 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGTCTTCTTCTGAGGCAGCA,  downstream forward: _UP4_GTAAAAGGATAAAGGAGGAA
References
23175651,21815947,12618455,10092453,21347729,21398478,18033289

1F245030D0C81DC96FC0642199CA00579CF46D06

Page visits: 3361

Time of last update: 2022-11-28 22:38:53

Author of last update: Melvin.boenninger