menB

menB
168

naphthoate synthase

locus
BSU_30800
Molecular weight
29.75 kDa
pI
5.34
Protein length
Gene length
function
biosynthesis of menaquinone
product
naphthoate synthase
essential
yes
ec
4.1.3.36
synonyms
menB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0447

This gene is a member of the following regulons

Gene
Coordinates
3,148,901  3,149,716
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
2-succinylbenzoyl-CoA + H+ --> 1,4-dihydroxy-2-naphthoyl-CoA + H2O (according to UniProt)
Protein family
[wiki|enoyl-CoA hydratase/isomerase family] (according to UniProt)
Structure
[PDB|1RJM] (from ''Mycobacterium tuberculosis'', 48% identity, 61% similarity)
[AF|P23966]
Modification
phosphorylated on Arg-78 and Arg-269 [Pubmed|31221751,22517742]
Expression and Regulation
Operons
genes
[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
Open in new tab

[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]→[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]

2022-12-29 18:48:47

ghost

29

c8390ec183bfac05f12ebb94a80cf07cf1992fec

43D6A4FCF35A0BD074DE7BBC94193C874185009D

genes
[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]-[gene|E3283812B7EB374EAC8722ECCE28432DE24B7B4C|menD]-[gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]-[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
description
[Pubmed|9387221,1629163,8550504]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8550504], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
Open in new tab

[gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]→[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]

2022-12-29 18:48:48

ghost

38

a92ddbfdf5b67e100c673490a9f20821b9a45d89

AF4C2B1155E6061073411DDF2040DB62495353C0

References
9387221,1629163,8550504,22517742,31221751

224584953B0BC1AF666CD69372B2D53AC56F6752

Page visits: 2520

Time of last update: 2023-02-06 20:50:04

Author of last update: Melvin.boenninger