aspS

aspS
168

aspartyl-tRNA synthetase

locus
BSU_27550
Molecular weight
65.80 kDa
pI
4.65
Protein length
Gene length
function
translation
product
aspartyl-tRNA synthetase
essential
yes
ec
6.1.1.12
synonyms
aspS

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0173

This gene is a member of the following regulons

Gene
Coordinates
2,814,743 2,816,521
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-aspartate + tRNAAsx --> AMP + diphosphate + L-aspartyl-tRNAAsx (according to UniProt)
Protein family
[wiki|Class-II aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|1EQR] (from ''Escherichia coli'', 52% identity, 68% similarity) [Pubmed|10873442]
[AF|O32038]
Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|69C7EF7E76821FF3D9E866838B24C3866CA9C189|hisS]-[gene|2B61D17950ADE0247B0CF4AE33548E15C0DDCD9B|aspS]
regulation
induced by histidine or aspartate limitation ([wiki|T-box]) [Pubmed|19258532]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: transcriptional antitermination, via tRNA controlled [wiki|RNA switch], in [regulon|other_regulator:T-box|T-box]
Open in new tab

[gene|69C7EF7E76821FF3D9E866838B24C3866CA9C189|hisS]→[gene|2B61D17950ADE0247B0CF4AE33548E15C0DDCD9B|aspS]

2022-11-28 09:39:51

Jstuelk

25

93588a5ea574db697b96bea0c2bb438af53f1051

2E078F834F39052D1FF1E957F712D4887C9079D3

References
19258532,15378759,16493705,26804570

2B61D17950ADE0247B0CF4AE33548E15C0DDCD9B

Page visits: 2428

Time of last update: 2022-12-01 12:38:49

Author of last update: Melvin.boenninger