gerBA
168
nutrient receptor, germination response to the combination of [metabolite|glucose], [metabolite|fructose], and KCl
locus
BSU_35800
Molecular weight
53.62 kDa
pI
7.3
function
germination response to the combination of [metabolite|glucose], [metabolite|fructose], and KCl
product
part of the putative nutrient-gated [protein|3368743E6E03792DB83A38A19989123304DF7560|gerBA]-[protein|D70EC7C02BC79BED724489ABCB6356447F215B87|gerBB]-[protein|93D4D6864686E6E559E6CEFA69BAC77EEFAA1BE3|gerBC] ion channel
essential
no
synonyms
gerBA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5901 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,688,812 3,690,263
The protein
Catalyzed reaction/ biological activity
the [protein|3368743E6E03792DB83A38A19989123304DF7560|gerBA]-[protein|D70EC7C02BC79BED724489ABCB6356447F215B87|gerBB]-[protein|93D4D6864686E6E559E6CEFA69BAC77EEFAA1BE3|gerBC] ion channel likely releases ions from the spore core in response to [metabolite|asparagine], [metabolite|glucose], [metabolite|fructose] and K+ to trigger [category|SW.4.2.4|Germination], this requires the gerK locus [pubmed|37104613]
Protein family
[wiki|GerABKA family] (according to UniProt)
Structure
[PDB|6O59] (from B. megaterium, corresponds to aa 7 ... 264, 36.5% identity) [pubmed|31113879]
[AF|P39569]
Paralogous protein(s)
[protein|7CE0CAF27B1C0F507E783B8B80622270B00634FD|yfkQ], [protein|AE28299B0F274B189DD90554A5A4F7B9A9479B60|yndD], [protein|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA], [protein|EEDE6A22E91992ABCA677CAB7917B7168C5CB868|gerAA]
[wiki|Localization]
spore inner membrane [Pubmed|21696470]
Expression and Regulation
Operons
genes
[gene|3368743E6E03792DB83A38A19989123304DF7560|gerBA]-[gene|D70EC7C02BC79BED724489ABCB6356447F215B87|gerBB]-[gene|93D4D6864686E6E559E6CEFA69BAC77EEFAA1BE3|gerBC]
description
[Pubmed|8012571]
regulation
expressed late during sporulation in the forespore ([protein|search|SigG]) [Pubmed|15699190,8012571]
sigma factors
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]: sigma factor, [Pubmed|15699190,8012571], in [regulon|protein:5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG regulon]
additional information
700 molecules are present per spore [PubMed|23749970]
Biological materials
Mutant
BKE35800 ([gene|3368743E6E03792DB83A38A19989123304DF7560|gerBA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35800 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGTTTCTCTCCTTCTTA, downstream forward: _UP4_AACATCAGACAAAGGTGATG
BKK35800 ([gene|3368743E6E03792DB83A38A19989123304DF7560|gerBA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35800 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGTTTCTCTCCTTCTTA, downstream forward: _UP4_AACATCAGACAAAGGTGATG
References
Reviews
Original Publications
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Time of last update: 2025-07-16 23:30:43
Author of last update: Jstuelk