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fatR
168
transcriptional repressor of the [gene|3DA3FFB295F5513A220CB163994EE0F356C810E6|fatR]-[gene|4BA5214C441C6671CB7DAA3CACBCA5FC025BE0E6|yrhJ] operon
locus
BSU_27170
Molecular weight
22.07 kDa
pI
5.62
function
unknown
product
transcriptional repressor of the [gene|3DA3FFB295F5513A220CB163994EE0F356C810E6|fatR]-[gene|4BA5214C441C6671CB7DAA3CACBCA5FC025BE0E6|yrhJ] operon ([wiki|TetR family])
essential
no
synonyms
fatR, yrhI, bscR
outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
Gene
Coordinates
2,777,070 2,777,654
The protein
Protein family
[wiki|TetR family]
[wiki|Domains]
[wiki|HTH tetR-type domain] (aa 6-66) (according to UniProt)
Structure
[PDB|4ME9] (from B. cereus, 38% identity)
[AF|O08335]
Modification
phosphorylated by [protein|6100EA37592A2C31BC3DE79AD7948A8D6F65F6E1|ptkA] on Tyr-45, this results in displacement of FatR from the DNA [Pubmed|23939619]
Expression and Regulation
Operons
genes
[gene|3DA3FFB295F5513A220CB163994EE0F356C810E6|fatR]-[gene|4BA5214C441C6671CB7DAA3CACBCA5FC025BE0E6|yrhJ]
description
[Pubmed|10917605]
regulation
expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]
regulatory mechanism
[protein|3DA3FFB295F5513A220CB163994EE0F356C810E6|fatR]: repression, [Pubmed|11734890], in [regulon|protein:3DA3FFB295F5513A220CB163994EE0F356C810E6|fatR regulon]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|18179421,12775685], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]: sigma factor, [Pubmed|12207695], in [regulon|protein:3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW regulon]
[protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX]: sigma factor, [Pubmed|9636707], in [regulon|protein:E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX regulon]
additional information
A [protein|search|ncRNA] ([wiki|RnaC]) is encoded between '[protein|search|yrhK]' and '[protein|search|yrhJ]' [PubMed|25790031]
genes
[gene|6D5089931FBDB398A7FAF3C8DDF341EB4949AEFE|yrhH]-[gene|3DA3FFB295F5513A220CB163994EE0F356C810E6|fatR]-[gene|4BA5214C441C6671CB7DAA3CACBCA5FC025BE0E6|yrhJ]
description
[Pubmed|18179421]
regulation
Expressed under stress conditions ([protein|search|SigW], [protein|search|SigX]) [Pubmed|9683469]
additional information
A [protein|search|ncRNA] ([wiki|RnaC]) is encoded between '[protein|search|yrhK]' and '[protein|search|yrhJ]' [PubMed|25790031]
Biological materials
Mutant
MGNA-A177 (yrhI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/177 NBRP B. subtilis, Japan]
BKE27170 ([gene|3DA3FFB295F5513A220CB163994EE0F356C810E6|fatR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTAATCTGACAACCTCC, downstream forward: _UP4_CAAAAATAGGAAAGGGAGAT
BKK27170 ([gene|3DA3FFB295F5513A220CB163994EE0F356C810E6|fatR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTAATCTGACAACCTCC, downstream forward: _UP4_CAAAAATAGGAAAGGGAGAT
References
Page visits: 2671
Time of last update: 2022-05-24 20:06:19
Author of last update: Melvin.boenninger