gerAB

gerAB
168

alanine sensor, [wiki|germination] response to L-alanine, triggers premature [wiki|germination] in response to morphological defects during [wiki|sporulation]

locus
BSU_33060
Molecular weight
41.30 kDa
pI
9.6
Protein length
Gene length
function
germination response to L-alanine
product
alanine sensor
essential
no
synonyms
gerAB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5902

This gene is a member of the following regulons

Gene
Coordinates
3,392,199  3,393,296
Phenotypes of a mutant
suppresses the defects of [gene|40BCEB3648585961D22B71BBB4FB62EE4B3E360D|spoVV] mutant spores [pubmed|28605069]
The protein
Catalyzed reaction/ biological activity
triggers premature [wiki|germination] in response to morphological defects during [wiki|sporulation] [pubmed|28605069]
Protein family
[wiki|amino acid-polyamine-organocation (APC) superfamily] (according to UniProt)
[wiki|Spore germination protein (SGP) (TC 2.A.3.9) family] (according to UniProt)
Structure
[AF|P07869]
Paralogous protein(s)
[protein|B14179D0EF5D3493E5CDB8E15378A5088B4FFD10|yndE], [protein|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB], [protein|D70EC7C02BC79BED724489ABCB6356447F215B87|gerBB]
[wiki|Localization]
predicted to be an integral membrane protein with ten membrane-spanning helices [Pubmed|21378181]
inner spore membrane [Pubmed|26731423]
Expression and Regulation
Operons
genes
[gene|EEDE6A22E91992ABCA677CAB7917B7168C5CB868|gerAA]-[gene|5FF739B8C087207039BB6DC293EE77F59337ED0B|gerAB]-[gene|D937E26DF69D49B1341B37596AC6A8FBEEF8BA2E|gerAC]
description
[Pubmed|3110007]
regulation
expressed during sporulation in the forespore ([protein|search|SigF], [protein|search|SigG], [wiki|SpoVT]) [Pubmed|16497325,15699190,8755877]
regulatory mechanism
[protein|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT]: repression, [Pubmed|8755877], in [regulon|protein:01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT regulon]
sigma factors
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]: sigma factor, [Pubmed|15699190], in [regulon|protein:5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG regulon]
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|16497325], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
additional information
1,100 molecules are present per spore [PubMed|23749970]
Open in new tab

[gene|EEDE6A22E91992ABCA677CAB7917B7168C5CB868|gerAA]→[gene|D937E26DF69D49B1341B37596AC6A8FBEEF8BA2E|gerAC]

2022-12-29 19:27:39

ghost

44

0b30e2b65ff83889103eaceb2726933679280f16

FB9C2DA86BEDDEDF47C18987147D4007D840E75A

Biological materials
Mutant
BKE33060 ([gene|5FF739B8C087207039BB6DC293EE77F59337ED0B|gerAB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33060 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AACAATAGAAATACCTTGAA,  downstream forward: _UP4_CTCAAGAGGAGGATTACAAC
BKK33060 ([gene|5FF739B8C087207039BB6DC293EE77F59337ED0B|gerAB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33060 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AACAATAGAAATACCTTGAA,  downstream forward: _UP4_CTCAAGAGGAGGATTACAAC
References
Reviews
27337279
Original Publications
3110007,17573930,12670969,2110996,15774895,16497325,16352818,8755877,21378181,21378197,21696470,22327596,23396907,24916603,22343299,16740944,26731423,28605069,33917581,34780301,34824238

5FF739B8C087207039BB6DC293EE77F59337ED0B

Page visits: 1779

Time of last update: 2023-02-03 05:01:39

Author of last update: Jstuelk