ftsL

ftsL
168

[wiki|cell division] protein (septum formation), controls together with [protein|B317D7E51824DD70EF84E4D5D7290D601BF4FAB6|ezrA] dynamics of the [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] ring, part of the [wiki|divisome]

locus
BSU_15150
Molecular weight
12.93 kDa
pI
10.08
Protein length
Gene length
function
Z-ring maturation and focusing septal peptidoglycan synthesis
product
[wiki|cell division] protein, member of the [wiki|divisome]
essential
yes
synonyms
ftsL, ylxB, yllD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4839

This gene is a member of the following regulons

Gene
Coordinates
1,581,597  1,581,950
Phenotypes of a mutant
essential [Pubmed|12682299]
depletion results in decondensation of the [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] ring and lethal filamentation [pubmed|35943250]
The protein
Protein family
FtsL family (single member, according to UniProt)
Structure
[AF|Q07867]
Effectors of protein activity
degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP], stabilized against [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP] cleavage by [protein|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC] [Pubmed|20644139]
[wiki|Localization]
cell membrane (according to UniProt)
localizes to the division site, this depends on [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|ftsW] [Pubmed|27895631]
Expression and Regulation
Operons
genes
[gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|rsmH]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]
description
[Pubmed|8636036,8244929]
regulation
constitutively expressed [Pubmed|15758244]
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[gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]→[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]

2022-10-04 18:14:33

Jstuelk

41

d5321fe6b1e9387ca670f35171261c39867c1f3d

9D42077BFFD1B3A740698D26FB54D7B31E3FD0C7

additional information
FtsL is degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP] [PubMed|17020588]
Biological materials
Mutant
MGNA-B127 (ftsL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1126 NBRP B. subtilis, Japan]
FLAG-tag construct
GP2004 ''ftsL-3xFLAG ermC'' (based on [wiki|pGP1087]), available in [wiki|Jörg Stülke]'s lab
References
Reviews
20836086,33709487,35638784
Original Publications
9720875,10792716,16936019,16549676,17020588,8636036,10986263,11994149,10844672,19429628,20644139,21219466,23701187,20870765,286740701,29443967,33077634,35943250

79712F4CF884A660C71B45B3397AEFA5C0AFA683

Page visits: 3376

Time of last update: 2022-10-06 18:20:10

Author of last update: Jstuelk