cmpA

cmpA
168

cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis

locus
G8J2-20
Molecular weight
4.00 kDa
function
represses cortex assembly until the successful initiation of spore coat assembly
product
cortex morphogenic protein A, adapter protein targeting [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA] for degradation by [protein|search|ClpXP] upon spore envelope defects
synonyms
cmpA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
525,021 → 528,076
Phenotypes of a mutant
quicker progressing through the [wiki|sporulation ] cycle [Pubmed|22463703]
overexpression of CmpA results in heat-sensitive sporulation [Pubmed|22463703,26387458], this can be suppressed by mutations in ''[gene|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]'' and ''[gene|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]'' [Pubmed|26387458]
The protein
Catalyzed reaction/ biological activity
orchestrates spore coat and cortex assembly [Pubmed|22463703]
represses cortex assembly until spore coat assembly successfully initiates [Pubmed|22463703]
[wiki|Interactions]
[protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]-[protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA]) [Pubmed|26387458]
[protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA]-[protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA]) [Pubmed|26387458]
[wiki|Localization]
surface of the developing spore, this depends on a functional [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA] [Pubmed|22463703,26387458]
Expression and Regulation
Operons
genes
[gene|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA]
description
[Pubmed|22463703,20709900]
regulation
expressed in mother cell during [wiki|sporulation ] ([protein|search|SigE], [wiki|SpoIIID]) [Pubmed|22463703]
regulatory mechanism
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID]: activation, [Pubmed|22463703], in [regulon|protein:90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|22463703], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
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[gene|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA]

2022-11-23 00:02:47

ghost

15

07721ce3dad2334337e41936efc8ac19ad287aab

97265DD6B2BC301871646AFF525038A446E40421

References
Reviews
27227299,26418292,28408070
Original Publications
22463703,26387458,20709900

85DE3CB6CDA61C141C6030367C0A13BB642160B9

Page visits: 1571

Time of last update: 2022-11-28 21:27:42

Author of last update: Jstuelk