acpA

acpA
168

acyl carrier protein

locus
BSU_15920
Molecular weight
8.45 kDa
pI
3.59
Protein length
Gene length
function
fatty acid biosynthesis
product
acyl carrier protein
essential
yes
ec
null
synonyms
acpA, acpP

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0236

This gene is a member of the following regulons

Gene
Coordinates
1,665,337  1,665,570
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Protein family
acyl carrier protein (ACP) family (single member, according to UniProt)
[wiki|Domains]
[wiki|Carrier domain] (aa 2-77) (according to UniProt)
Structure
[PDB|1F80] (complex with [protein|200BE4802FCE3C860565B374EAADC9C1FEEF3E49|acpS]) [Pubmed|10997907],  [PDB|3EJE] (complex with [protein|8FBC9A1AC108DC99E275D7A27C18C797D3CDB936|bioI]) [Pubmed|18838690],  [PDB|1HY8]
[AF|P80643]
[wiki|Localization]
cytoplasm (according to Swiss-Prot), during sporulation in the mother cell [Pubmed|19850612]
Expression and Regulation
Operons
genes
[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]
description
[Pubmed|19850612]
regulatory mechanism
[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]: repression, [Pubmed|12737802], in [regulon|protein:FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16932747], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]

2022-12-29 13:56:46

Jstuelk

50

2b2779292614dc3dc941b307b725555b1c8e112a

0F5EFA51AA0469F0C9F2D1291AB60F14F33911DF

genes
[gene|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]-[gene|8F5612395EBF90BEF4C80056EECAFC572384E7F8|plsX]-[gene|BB8542A6444564B21FF5DB6E2C75192C6DA2DFB8|fabD]-[gene|439B468A13137000FB42E9389391CB4986FFED84|fabG]-[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]
description
[Pubmed|19850612]
regulation
''[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]'': repressed in the absence of malonyl-CoA or malonyl-[protein|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|ACP] ([protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]) [Pubmed|12737802]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]: repression, [Pubmed|12737802], in [regulon|protein:FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR regulon]
[protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]) [Pubmed|16091051], in [regulon|protein:7832489F11F606BCF637EC23BAAB41AD10237EBB|comA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16932747], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]→[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]

2023-02-01 13:38:07

Jstuelk

77

FFBE1C006C18216F03207DE6CCE7201A900066A3

A19B82B645D7251903097316A08D79733FD80DE9

Biological materials
Expression vectors
pGP2893: expression of Strep-''acpA'' by [wiki|pGP380] in ''B. subtilis'' suitable for [wiki|SPINE], available in [wiki|Jörg Stülke]'s lab
labs
[wiki|Diego de Mendoza], Universidad Nacional de Rosario, Argentine [http://www.ibr.gov.ar/eng/investigacion/demendoza.htm homepage]
References
Reviews
15952903,20658980
Original Publications
10997907,19850612,12737802,18838690,20201588,23033921,33782055

8D260693D0C69442BCB9F3D8480E8425ACFE34D2

Page visits: 2827

Time of last update: 2023-02-01 21:35:50

Author of last update: Robert.warneke