ileS

ileS
168

isoleucyl-tRNA synthetase

locus
BSU_15430
Molecular weight
104.58 kDa
pI
5.19
Protein length
Gene length
function
translation
product
isoleucyl-tRNA synthetase
essential
yes
ec
6.1.1.5
synonyms
ileS

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0060

This gene is a member of the following regulons

Gene
Coordinates
1,613,357  1,616,122
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-isoleucine + tRNAIle --> AMP + diphosphate + L-isoleucyl-tRNAIle (according to UniProt)
Protein family
[wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|1QU2] (from ''Staphylococcus aureus'', 61% identity) [Pubmed|10446055]
[AF|Q45477]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]
Expression and Regulation
Operons
genes
[gene|9C29039BB3EE70FEC91C0F0919E579E76EEB193A|ileS]
description
[pubmed|22383849]
regulation
induced by isoleucine limitation ([wiki|T-box]) [Pubmed|19258532]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: antitermination, [pubmed|19258532], in [regulon|other_regulator:T-box|T-box]
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[gene|9C29039BB3EE70FEC91C0F0919E579E76EEB193A|ileS]

2022-11-18 16:38:51

Jstuelk

28

cca36f836dcc46671e62ee28396c5cb70f872254

D76E59801B25510A5E4077D954B21FD2F8CA3DA8

References
19258532,10446055,17981983,19233850,28139725,29794222,35357484

9C29039BB3EE70FEC91C0F0919E579E76EEB193A

Page visits: 1810

Time of last update: 2022-11-27 03:26:25

Author of last update: Jstuelk