gyrA

gyrA
168

DNA gyrase (subunit A)

locus
BSU_00070
Molecular weight
91.91 kDa
pI
5.22
Protein length
Gene length
function
DNA supercoiling, control of [category|SW.3.1.1|replication] initiation, resolution of head-on [category|SW.3.1.1|DNA replication]-[category|SW.3.2.1|Transcription] conflicts
product
DNA gyrase (subunit A)
essential
yes
ec
5.99.1.3
synonyms
gyrA, nalA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0188

This gene is a member of the following regulons

Gene
Coordinates
6,994 → 9,459
Phenotypes of a mutant
essential [Pubmed|12682299]
enhanced colony wrinkling upon knockdown [pubmed|36069446]
The protein
Catalyzed reaction/ biological activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to UniProt)
decreases [protein|6740108089F13116F200C15F35C2E7561E990FEB|dnaA] association with the oriC and inhibits [category|SW.3.1.1|replication] initiation [pubmed|29396913]
Protein family
Topoisomerase IIA [protein|B207C7328177924B16F1C606F667BEADF12CA069|gyrA]/[protein|9075DD0CC0B8554F0379732453665F43C70EFC26|parC] subunit family (together with [protein|9075DD0CC0B8554F0379732453665F43C70EFC26|parC]) (according to UniProt)
Structure
[PDB|4DDQ] (DNA gyrase A-subunit lacking the C-terminal DNA-wrapping domains) [Pubmed|23602808]
[AF|P05653]
Paralogous protein(s)
[protein|9075DD0CC0B8554F0379732453665F43C70EFC26|parC]
[wiki|Localization]
Nucleoid (Homogeneous) [Pubmed|16479537]
nucleoid-associated in actively growing cells [Pubmed|9539793]
Expression and Regulation
Operons
genes
[gene|FB1C21A94697E5B9D29C0F3B9C9F36E57BCBD237|yaaA]-[gene|EBE03AEC7EC594A3115A7A72194BDFF300AA0BFA|recF]-[gene|CBC76FB453569550F14FE5015C05D45985C04979|remB]-[gene|AA42910B71348EFEA4165CFFCEF1E497897B9DDC|gyrB]-[gene|B207C7328177924B16F1C606F667BEADF12CA069|gyrA]
description
[Pubmed|22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2987848], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|FB1C21A94697E5B9D29C0F3B9C9F36E57BCBD237|yaaA]→[gene|B207C7328177924B16F1C606F667BEADF12CA069|gyrA]

2022-11-29 20:03:17

Jstuelk

50

7cfa0ee36064fef3f7a603b125c665e7c80f35bd

A6120E836ADBF13F415EC7E80D314C2CE36E1D65

labs
[wiki|Dagmar Klostermeier], University of Münster, Germany, [http://www.biozentrum.unibas.ch/klostermeier/index.html homepage]
References
Reviews
16936698,29772727,33480441,33959387
Original Publications
16479537,17981983,9539793,2987848,19666507,17320901,23475963,23602808,20870749,24563461,27557712,27793284,12767818,6282812,29396913,8940171,7590259,10944214,6248518,6243420,225110,17334374,30457554,30517674,31953321,33657379,36069446

B207C7328177924B16F1C606F667BEADF12CA069

Page visits: 7006

Time of last update: 2022-12-05 16:43:52

Author of last update: Jstuelk