prp

prp
168

protein cysteine protease, required for N-terminal cleavage of [protein|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|ribosomal protein L27]

locus
BSU_27950
Molecular weight
12.16 kDa
pI
4.46
Protein length
Gene length
function
maturation of [protein|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|ribosomal protein L27]
product
[protein|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|ribosomal protein L27] cysteine protease
essential
yes
synonyms
prp, ysxB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2868

This gene is a member of the following regulons

Gene
Coordinates
2,855,177 → 2,855,515
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
N-terminal cleavage of [protein|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|ribosomal protein L27] [Pubmed|25388641]
Structure
[PDB|2P92] (the protein from ''S. aureus'')
[AF|P26942]
Expression and Regulation
Operons
genes
[gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]-[gene|B27548A4BBF396C9BA102A80ACB08B21262CEA30|prp]-[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
description
[Pubmed|22383849]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
likely autorepression of the [gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA] operon expression upon binding of excess of one ribosomal protein to the untranslated region of the [gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA] mRNA [Pubmed|17616982]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
Open in new tab

[gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]

2023-01-17 18:52:56

Jstuelk

41

8f3fdba1f688b7c526a0b1e5093a21e24d385eba

2B427CEB8C26458F794890CD1011223BA52E2EDB

genes
[gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]-[gene|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A|spoIVFB]-[gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]-[gene|B27548A4BBF396C9BA102A80ACB08B21262CEA30|prp]-[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
description
[Pubmed|22383849]
regulation
expressed early during sporulation in the mother cell ([protein|search|SigE], [wiki|SpoIIID]) [Pubmed|15699190,1942049,15383836]
additional information
the domains that inhibits [protein|search|SpoIVFB] is cleaved off by [protein|search|CtpB] (second cleavage) [PubMed|24243021]
Open in new tab

[gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]

2022-12-30 13:20:33

ghost

52

08f2f6d702f3f60218799ff9efc97a2139d25593

976520A55B5743F327D2763CEA04F353CE09CEE1

References
Reviews
34410368
Original Publications
11948165,25388641,22383849,28187498,28189581

B27548A4BBF396C9BA102A80ACB08B21262CEA30

Page visits: 1489

Time of last update: 2023-01-26 15:41:31

Author of last update: Jstuelk