divIB
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divIB
168

cell-division initiation protein (septum formation)

locus
BSU_15240
Molecular weight
30.02 kDa
pI
9.24
Protein length
Gene length
function
septum formation
product
cell-division protein, member of the [wiki|divisome]
essential
yes
synonyms
divIB, dds, tms-12

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1589

This gene is a member of the following regulons

Gene
Coordinates
1,593,704 → 1,594,495
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Protein family
FtsQ/DivIB family (single member, according to UniProt)
[wiki|Domains]
POTRA domain (aa 54-123) (according to UniProt)
Structure
[PDB|2ALJ] (major extracytoplasmic domain, Geobacillus stearothermophilus)
[AF|P16655]
[wiki|Localization]
cell membrane [Pubmed|9426141]
Expression and Regulation
Operons
genes
[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]-[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
description
[Pubmed|18179421]
regulation
expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|1391053]
regulatory mechanism
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID]: repression, [Pubmed|15383836], in [regulon|protein:90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID regulon]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, (promoter within [protein|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]) [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8106328], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|8320223], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Open in new tab

[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]→[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]

2022-07-31 10:20:51

Jstuelk

24

5a24cdfec598f0a2424898f47e06e5544408d3d6

1A7F525A9A274FAF9AE05A426F5AE7383E95D9E3

genes
[gene|D48B7591467C493D2214D37AEA83643FE8C27BC6|murE]-[gene|4D3D4429E1F387BACB0D5A1084AA8DF179A16685|mraY]-[gene|0A9FF5A66F73464A780914A1424979CE753B3D9C|murD]-[gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]-[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]-[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
description
[Pubmed|1391053]
regulation
expressed during vegatative growth [Pubmed|1391053]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID]: repression, [Pubmed|15383836], in [regulon|protein:90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|8320223], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Open in new tab

[gene|D48B7591467C493D2214D37AEA83643FE8C27BC6|murE]→[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]

2022-08-12 09:07:34

Jstuelk

24

68c6899b3f1263bd636c35a4ea9512c00078a714

2F040145AC628A38E3D11955965F4DA256DE6790

genes
[gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]-[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]-[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
description
[Pubmed|1391053]
regulation
expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|1391053]
Open in new tab

[gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]→[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]

2022-07-24 14:58:30

Jstuelk

22

6fa043950e40c3a1d4f91339581472acb9db18da

C066C3357FB70D8EEB595C678C068B56731F8F59

genes
[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
description
[Pubmed|8106328]
Open in new tab

[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]→[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]

2022-06-10 19:31:34

Jstuelk

19

f37d9a564efeec39a2ef7291ea255a7cf0bf6960

DC16386FDAC4B973DDD9A4C0BCD3FF866F63C22D

genes
[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
description
[Pubmed|18179421]
regulation
expressed during vegatative growth, then switched off, and again expressed during [wiki|sporulation ]in the mother cell ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|1391053]
Open in new tab

[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]→[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]

2022-08-10 02:11:12

Jstuelk

26

3d08ab9489a62734a3c1b81d0d7a7e15bf37e1dc

F5945D130AA23B8820F36AD12C2F42D0A674910E

Biological materials
FLAG-tag construct
GP2005 ''divIB-3xFLAG ermC'' (based on [wiki|pGP1087]), available in [wiki|Jörg Stülke]'s lab
References
Reviews
35638784
Original Publications
8459777,10852898,19429628,1391053,21219466,8320223,8106328,18179421,15659156,16936019,10217758,10792716,9720875,16936026,9426141,9044263,29443967,32749956,33077634,33737746

B66FC02948DABBCE64DE2629D6E33E05647B4EEF

Page visits: 3923

Time of last update: 2022-08-16 20:27:40

Author of last update: Jstuelk