fabD

fabD
168

malonyl CoA-acyl carrier protein transacylase

locus
BSU_15900
Molecular weight
33.88 kDa
pI
4.51
Protein length
Gene length
function
fatty acid biosynthesis
product
malonyl CoA-acyl carrier protein transacylase
essential
yes
ec
2.3.1.39
synonyms
fabD, ylpE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0331

This gene is a member of the following regulons

Gene
Coordinates
1,663,567 → 1,664,520
Phenotypes of a mutant
essential [Pubmed|12682299]
enhanced colony wrinkling upon knockdown [pubmed|36069446]
The protein
Catalyzed reaction/ biological activity
holo-[ACP] + malonyl-CoA --> CoA + malonyl-[ACP] (according to UniProt)
Protein family
fabD family (with [protein|55C821F68B2E5F9F45CC2B2C9494D48D5C33266A|pksC] and [protein|CB0B856B22984DD5B10F01DD07C3961FAA742923|pksE], according to UniProt)
Structure
[PDB|1MLA] (the enzyme from ''E. coli'') [Pubmed|7768883]
[AF|P71019]
Expression and Regulation
Operons
genes
[gene|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]-[gene|8F5612395EBF90BEF4C80056EECAFC572384E7F8|plsX]-[gene|BB8542A6444564B21FF5DB6E2C75192C6DA2DFB8|fabD]-[gene|439B468A13137000FB42E9389391CB4986FFED84|fabG]-[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]
description
[Pubmed|19850612]
regulation
''[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]'': repressed in the absence of malonyl-CoA or malonyl-[protein|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|ACP] ([protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]) [Pubmed|12737802]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]: repression, [Pubmed|12737802], in [regulon|protein:FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR regulon]
[protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]) [Pubmed|16091051], in [regulon|protein:7832489F11F606BCF637EC23BAAB41AD10237EBB|comA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16932747], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]→[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]

2022-12-08 20:10:40

Jstuelk

64

FFBE1C006C18216F03207DE6CCE7201A900066A3

A19B82B645D7251903097316A08D79733FD80DE9

References
Reviews
15952903
Original Publications
12737802,16932747,19850612,7768883,16091051,36069446

BB8542A6444564B21FF5DB6E2C75192C6DA2DFB8

Page visits: 2437

Time of last update: 2022-12-06 13:36:30

Author of last update: Jstuelk