spoVAF
168
part of an ion channel for spore germination, amplifies the response to spore germinants
locus
BSU_23390
Molecular weight
55.44 kDa
pI
6.21
function
spore germination
product
part of the [protein|CBE5093DFBBCE25071CCE12408BC9AFF7A158C03|spoVAF]-[protein|449EEBF33F52B461F244331ACD140E68CF64EE7C|figP] heteromeric ion channel
essential
no
synonyms
spoVAF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5840 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,438,372 → 2,439,853
Phenotypes of a mutant
delayed germination with germinant receptor-dependent germinants [Pubmed|24682327]
The protein
Catalyzed reaction/ biological activity
the [protein|CBE5093DFBBCE25071CCE12408BC9AFF7A158C03|spoVAF]-[protein|449EEBF33F52B461F244331ACD140E68CF64EE7C|figP] ion channel releases K+ under high pressure conditions [pubmed|39835809]
Protein family
[wiki|GerABKA family] (according to UniProt)
Structure
[AF|P31845]
[wiki|Localization]
integral inner spore membrane protein [Pubmed|24682327]
Expression and Regulation
Operons
genes
[gene|5410018998EC9792A69CF0D9C438EEF5AC8A82C5|spoVAA]-[gene|AEC70413BDC29F435776D532E7049AA9A0BD893D|spoVAB]-[gene|B280951A232E941FB0A6C8834049765BE1E16437|spoVAC]-[gene|9531F0A0DC4AE5696FFBAC9C2A773F15840E3255|spoVAD]-[gene|31D6CB7EC20C39C1815CA4552B8B9C4BE304E86B|spoVAEB]-[gene|B44529B69769D7AF1010E06C95E398EA91A3E798|spoVAEA]-[gene|CBE5093DFBBCE25071CCE12408BC9AFF7A158C03|spoVAF]-[gene|02F1C926D200DE85C93A0ACEF23AD25FBD12B0BD|lysA]
description
[Pubmed|7934830]
regulation
expressed late during sporulation in the forespore ([protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG], [wiki|SpoVT]) [Pubmed|15699190,1903432,8755877]
regulatory mechanism
[protein|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT]: activation, [Pubmed|8755877], in [regulon|protein:01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT regulon]
sigma factors
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]: sigma factor, [Pubmed|15699190,1903432], in [regulon|protein:5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG regulon]
Biological materials
Mutant
BKE23390 (Δ[gene|CBE5093DFBBCE25071CCE12408BC9AFF7A158C03|spoVAF]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23390 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ACGGTTTTTGAAATACTCTT, downstream forward: _UP4_TAATCGCATTGAAACTGACT
BKK23390 (Δ[gene|CBE5093DFBBCE25071CCE12408BC9AFF7A158C03|spoVAF]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23390 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ACGGTTTTTGAAATACTCTT, downstream forward: _UP4_TAATCGCATTGAAACTGACT
References
Reviews
Original Publications
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Time of last update: 2025-07-16 09:14:28
Author of last update: Jstuelk