murE

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murE
168

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase

locus
BSU_15180
Molecular weight
54.16 kDa
pI
5.56
Protein length
Gene length
function
peptidoglycan precursor biosynthesis
product
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase
essential
yes
ec
6.3.2.13
synonyms
murE

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0769

This gene is a member of the following regulons

Gene
Coordinates
1,586,330 → 1,587,814
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + meso-2,6-diaminopimelate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate --> ADP + H+ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-diaminopimelate (according to UniProt)
Protein family
[wiki|MurCDEF family] (according to UniProt)
Structure
[PDB|2WTZ] (from ''Mycobacterium tuberculosis'', 35% identity, 50% similarity) [Pubmed|19945347]
[AF|Q03523]
[wiki|Localization]
forms banded patterns along the length of the cell, this pattern formation depends on [protein|A4C8719E06F774A6EB4D79757CC79CF89E453A54|mreB] [Pubmed|20233306]
Expression and Regulation
Operons
genes
[gene|D48B7591467C493D2214D37AEA83643FE8C27BC6|murE]-[gene|4D3D4429E1F387BACB0D5A1084AA8DF179A16685|mraY]-[gene|0A9FF5A66F73464A780914A1424979CE753B3D9C|murD]-[gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]-[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]-[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
description
[Pubmed|1391053]
regulation
expressed during vegatative growth [Pubmed|1391053]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID]: repression, [Pubmed|15383836], in [regulon|protein:90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|8320223], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Open in new tab

[gene|D48B7591467C493D2214D37AEA83643FE8C27BC6|murE]→[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]

2022-04-27 17:36:38

Jstuelk

21

68c6899b3f1263bd636c35a4ea9512c00078a714

2F040145AC628A38E3D11955965F4DA256DE6790

References
8436954,18063720,11948165,1391053,20233306,29456081

D48B7591467C493D2214D37AEA83643FE8C27BC6

Page visits: 3753

Time of last update: 2022-05-25 10:14:29

Author of last update: Melvin.boenninger