cysS

cysS
168

cysteine-tRNA synthetase

locus
BSU_00940
Molecular weight
53.74 kDa
pI
5.07
Protein length
Gene length
function
translation
product
cysteine-tRNA synthetase
essential
yes
ec
6.1.1.16
synonyms
cysS, snpA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0215

This gene is a member of the following regulons

Gene
Coordinates
113,450 → 114,850
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-cysteine + tRNACys --> AMP + diphosphate + L-cysteinyl-tRNACys (according to UniProt)
Protein family
[wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|1U0B] (from ''Escherichia coli'', 42% identity, 56% similarity) [Pubmed|15489861]
[AF|Q06752]
Modification
phosphorylation on Ser-270 [Pubmed|17218307]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|132E91DB8C81CD8C4F5160B2C068B74DA10AE224|gltX]-[gene|5B9D5DA130DC3654F386684156BDC350DD05DB60|cysE]-[gene|E5826A99769E2FE45959A9D623D6467A8DDDEB81|cysS]-[gene|031FDF8443A8A4D5B042B7591EBE2E6C74F07702|mrnC]-[gene|8CB595F84D00D1262EB13E6CF47BE6F00EDE16A5|yacO]-[gene|172652156ABFE72D5BAAC22729CE17CA947538B5|yacP]
description
[Pubmed|7510287]
regulation
expression transiently increases in the forespore [Pubmed|22848659]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: transcription antitermination, overlaps a transcription terminator upstream of [gene|5B9D5DA130DC3654F386684156BDC350DD05DB60|cysE], in [regulon|other_regulator:T-box|T-box]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7510287], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|132E91DB8C81CD8C4F5160B2C068B74DA10AE224|gltX]→[gene|172652156ABFE72D5BAAC22729CE17CA947538B5|yacP]

2022-11-24 18:26:23

Jstuelk

26

9ab774439b3983729fe5811aeaf44f4bc16c609f

BCC6FA512C81F405B92E34AE44A52F949D245F3D

References
19258532,17218307,7510287

E5826A99769E2FE45959A9D623D6467A8DDDEB81

Page visits: 1947

Time of last update: 2022-11-30 07:36:33

Author of last update: Melvin.boenninger