ctaF

168

cytochrome-c oxidase (caa₃) (subunit IV)

locus: BSU_14920

Molecular weight: 12.48 kDa

pI: 9.88

Protein length: 110 aa

Gene length: 333 bp

function: respiration

product: cytochrome-c oxidase (subunit IV)

essential: no

ec: 1.9.3.1

synonyms: ctaF

List of homologs in different organisms, belongs to COG3125 (Galperin et al., 2021)

Gene

Coordinates: 1,564,063  1,564,395

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The protein

Catalyzed reaction/ biological activity

• 4 [Fe(II)cytochrome c] + 4 H⁺ + O₂ --> 4 [Fe(III)cytochrome c] + 2 H₂O (according to UniProt)

Protein family

• cytochrome c oxidase bacterial subunit 4 family (with [protein|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD], according to UniProt)

Structure

• [AF|P24013]

[wiki|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]-[gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]-[gene|20D1174554A03EECE233A1A045F6DF83AF799959|ctaD]-[gene|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|ctaE]-[gene|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF]-[gene|8C16E115CB59A74C24954BFCDE112720BA09D5EA|ctaG]

  description: [Pubmed|9829923]

  regulation

  • expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]) [Pubmed|9829923]

  regulatory mechanism

  • [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|9829923], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
  • [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh]: repression, synergistic repression with [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB], in [regulon|protein:5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, synergistic repression with [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]

Biological materials

Mutant

• BKE14920 ([gene|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14920 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TCTGCTTTTTTTATCGACCA,  downstream forward: _UP4_TAATTTGAACAGCCGCCGGA
• BKK14920 ([gene|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14920 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TCTGCTTTTTTTATCGACCA,  downstream forward: _UP4_TAATTTGAACAGCCGCCGGA

References

Reviews

• 33705278

Original Publications

• 20817675,10551842,9829923,27503613,36422766