metA

metA
168

homoserine O-succinyltransferase

locus
BSU_21910
Molecular weight
25.85 kDa
pI
6.41
Protein length
Gene length
function
biosynthesis of methionine
product
homoserine O-succinyltransferase
essential
no
ec
2.3.1.46
synonyms
metA, metB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1897 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,305,378  2,306,283
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The protein
Catalyzed reaction/ biological activity
acetyl-CoA + L-homoserine --> CoA + O-acetyl-L-homoserine (according to UniProt)
Protein family
MetA family (single member, according to UniProt)
Structure
[PDB|2GHR] (from ''Bacillus cereus'', 60% identity, 77% similarity) [Pubmed|17546672]
[AF|P54167]
Expression and Regulation
Operons
genes
[gene|1217330ECD588E24E42FF9FED2A097CEF32785F3|metA]-[gene|7A606B8E952AE8CA4F9A62008BA4B156725BB5B5|ugtP]
description
[Pubmed|22383849]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
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[gene|1217330ECD588E24E42FF9FED2A097CEF32785F3|metA]→[gene|7A606B8E952AE8CA4F9A62008BA4B156725BB5B5|ugtP]

2024-03-06 03:55:03

ghost

72

45e856ff37b7ee445afb9c87f96abb81194264ae

4B45D0C21B6BA8DCA11EA8FC7ACD2A28343A2152

Biological materials
Mutant
BKE21910 ([gene|1217330ECD588E24E42FF9FED2A097CEF32785F3|metA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE21910 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAACGTGCCACCTCCATTAT,  downstream forward: _UP4_TAATTTTTCTTTTTTTAGTG
BKK21910 ([gene|1217330ECD588E24E42FF9FED2A097CEF32785F3|metA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK21910 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAACGTGCCACCTCCATTAT,  downstream forward: _UP4_TAATTTTTCTTTTTTTAGTG
References
17546672,18179421,28581482

1217330ECD588E24E42FF9FED2A097CEF32785F3

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Time of last update: 2024-03-28 20:01:16

Author of last update: Melvin.boenninger