mutT

mutT
168

antimutator protein, has RNA pyrophosphohydrolase activity

locus
BSU_04330
Molecular weight
16.26 kDa
pI
8.59
Protein length
Gene length
function
DNA repair, protection against oxidative stress
product
antimutator protein
essential
no
synonyms
mutT

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1051 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
488,314  488,763
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
8-oxo-dGTP + H2O --> 8-oxo-dGMP + diphosphate + H+ (according to UniProt)
Protein family
[wiki|Nudix hydrolase] (according to UniProt)
[wiki|Domains]
[wiki|Nudix hydrolase domain] (aa 1-123) (according to UniProt)
[wiki|Cofactors]
Mn2+ [pubmed|31740579]
Structure
[PDB|1VC8] (N-terminal 100 amino acids of Ap6A hydrolase from Thermus thermophilus, 40% identity)
[AF|P96590]
Biological materials
Mutant
MGNA-C093 (mutT::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2091 NBRP B. subtilis, Japan]
JH642 and its derivatives: natural deletion of the 18 kb [gene|467E9CF20B545A976614968E7DD5497F9390D344|ydzA]-[gene|353DADE8E57A0F1895CCEB62701F9273EEB5EB45|mntH] region encompassing the genes [gene|467E9CF20B545A976614968E7DD5497F9390D344|ydzA]-[gene|7D5327BD1DD5FD5F90B2C849589923AA3D8B20EF|topB]-[gene|69DEE29383E40F49890CC8314DFBF56D70D35113|ydaJ]-[gene|70ED3CE683F3A3F785480F40986CABE7729C17C7|ydaK]-[gene|28D80C5497AE29A24AD6B9A1A713A2B3915F2CED|ydaL]-[gene|961538BEDD27C24FC073AFB7AB3268E3D46783CC|ydaM]-[gene|ADE0122D8FFF2F78B6D21031B7D02A323A13ED63|ydaN]-[gene|5968E6D4D7378C69EC3E1E05B285069123AA1FD3|kimA]-[gene|6085BDAD40F719555EA4EEA7BBAD74103BD03D0F|mutT]-[gene|2883FC60CD69948D5C43BDDFEFBE7A1CA7C743C7|ydaP]-[gene|87834D5C47064BEFF26F086A8202C311F28F9D38|ydzK]-[gene|search|mntH ][pubmed|18670626]
BKE04330 ([gene|6085BDAD40F719555EA4EEA7BBAD74103BD03D0F|mutT]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE04330 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACCCCCATACCTCCTTTTC,  downstream forward: _UP4_TGATTCAGGTCTCCGGGTTT
BKK04330 ([gene|6085BDAD40F719555EA4EEA7BBAD74103BD03D0F|mutT]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK04330 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACCCCCATACCTCCTTTTC,  downstream forward: _UP4_TGATTCAGGTCTCCGGGTTT
References
16513759,31740579

6085BDAD40F719555EA4EEA7BBAD74103BD03D0F

Page visits: 1783

Time of last update: 2024-03-27 11:31:36

Author of last update: Jstuelk