phrA

168

response regulator aspartate phosphatase ([protein|25D89EF3C4D57B3E6F9AB0210029651F74356906|rapA]) inhibitor, control of the [wiki|phosphorelay]

locus: BSU_12440

Molecular weight: 4.66 kDa

pI: 10.23

Protein length: 44 aa

Gene length: 135 bp

function: control of [wiki|sporulation] initiation

product: phosphatase ([protein|25D89EF3C4D57B3E6F9AB0210029651F74356906|rapA]) inhibitor

essential: no

synonyms: phrA, gsiAB

List of homologs in different organisms

Gene

Coordinates: 1,316,995 → 1,317,129

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The protein

Protein family

• [wiki|phr family] (according to UniProt)

Structure

• [AF|Q00829]

Expression and Regulation

Operons

• genes: [gene|25D89EF3C4D57B3E6F9AB0210029651F74356906|rapA]-[gene|D31B325366D3F0169E4ECA8871645C7826019C10|phrA]

  description: [Pubmed|1378051]

  regulation

  • expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]

  regulatory mechanism

  • [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
  • [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]) [Pubmed|16091051], in [regulon|protein:7832489F11F606BCF637EC23BAAB41AD10237EBB|comA regulon]
  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|23569278,12618455], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|12850135], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1378051], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]

Biological materials

Mutant

• BKE12440 (Δ[gene|D31B325366D3F0169E4ECA8871645C7826019C10|phrA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE12440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATTTAGATTTCATATAAACA,  downstream forward: _UP4_TGATGCATAAAAAAAGACCC
• BKK12440 (Δ[gene|D31B325366D3F0169E4ECA8871645C7826019C10|phrA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK12440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATTTAGATTTCATATAAACA,  downstream forward: _UP4_TGATGCATAAAAAAAGACCC

References

Reviews

• 37042030

Original Publications

• 8643670,8730857,11923303,1378051,14651647,12618455,12107147,19380751,16091051,20238180,27122155,32132526